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Temperature and concentration imaging method of magnetic nanoparticles

A magnetic nanoparticle and imaging method technology, which is applied in the field of nanomaterial testing, can solve the problems of low spatial resolution and low precision, and achieve the effect of improving spatial resolution and high accuracy of calculation results

Active Publication Date: 2019-08-30
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a temperature and concentration imaging method of magnetic nanoparticles, which is used to solve the technical problems of low spatial resolution and low accuracy of the temperature measurement results caused by the influence of the environment in the existing nuclear magnetic resonance temperature imaging technology

Method used

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  • Temperature and concentration imaging method of magnetic nanoparticles
  • Temperature and concentration imaging method of magnetic nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A temperature and concentration imaging method 100 of magnetic nanoparticles, such as figure 1 shown, including:

[0048] Step 110, using a DC gradient magnetic field to generate a zero magnetic field space in the magnetic nanoparticle reagent;

[0049] Step 120, using a stepped triangular wave to drive the magnetic field to change the position of the zero magnetic field point in the zero magnetic field space in the area to be imaged of the magnetic nanoparticle reagent;

[0050] Step 130: At each position, apply pulsed static magnetic fields with different magnetic field strengths and corresponding radio frequency pulses, and detect the magnetic nanoparticle reagent at this position under each magnetic field strength through the detection coil arranged in the pulsed static magnetic field. The first resonant frequency, and based on the second resonant frequency of the pure reagent respectively, the amount of frequency variation of the magnetic nanoparticle reagent rela...

example 2

[0100] Simulation example two (two-dimensional imaging):

[0101] (1) Simulation model and test description:

[0102] In order to study the feasibility and superiority of using magnetic resonance frequency to solve the magnetic susceptibility of magnetic nanoparticles and realize temperature imaging, in a two-dimensional space with a size of 15×15mm and 81×81 pixels, set the pulse static magnetic field strength to 0.05T, 0.06T, the absolute temperature T range is 295-335K, the transverse and longitudinal DC gradient magnetic field gradient G is 8T / m, the particle size of magnetic nanoparticles is 5nm, and the saturation magnetization of magnetic nanoparticles is M s It is 477kA / m, and the imaging simulation analysis of this method is carried out. The concentration imaging simulation results when the absolute temperature T is 300K are as follows: Figure 5 ; The temperature imaging simulation results when the absolute temperature T range of the imaging field of view is 295-33...

Embodiment 2

[0108] A storage medium, in which instructions are stored, and when a computer reads the instructions, the computer is made to execute any one of the above magnetic nanoparticle temperature and concentration imaging methods.

[0109] The relevant technical solutions are the same as those in Embodiment 1, and will not be repeated here.

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Abstract

The invention discloses a temperature and concentration imaging method of magnetic nanoparticles. The method comprises the steps of generating zero magnetic field points by using a gradient magnetic field, determining a sample spatial position activating a magnetic resonance signal, controlling the positions of zero magnetic field points of a direct current gradient magnetic field by using step triangular wave driving magnetic fields in different directions, applying a pulse static magnetic field and radio frequency pulse waves, detecting magnetic resonance frequency information of a magneticnanoparticle liquid sample, obtaining concentration information and temperature information of the magnetic nanoparticles by using a relationship between resonance frequencies and magnetisability of the magnetic nanoparticles according to resonance frequencies of a magnetic nano reagent in different spatial positions within an imaging scope, and finally, achieving magnetic nano temperature imaging. The method achieves the temperature imaging through the concentration information and the temperature information of the magnetic nanoparticles obtained by using a nuclear magnetic resonance technology, effectively increases spatial resolution of magnetic nanoparticle imaging and achieves temperature distribution imaging. According to simulation data, the spatial resolution of the magnetic nanoimaging can be increased and the temperature imaging can be achieved by using the magnetic resonance frequencies for the temperature imaging.

Description

technical field [0001] The invention relates to the technical field of nanometer material testing, in particular to a temperature and concentration imaging method of magnetic nanoparticles. Background technique [0002] Tumor hyperthermia guided by magnetic resonance temperature imaging technology, as a combination of tumor hyperthermia technology and non-invasive thermometry technology, is the focus of clinical tumor physiotherapy research. Compared with other non-invasive temperature measurement methods, magnetic resonance temperature imaging technology will not cause harm to the human body, and can perform imaging at any angle, and can well identify tumors and surrounding tissues. However, the principle of magnetic resonance imaging determines that its measurement results will be affected by factors such as the physiological activities of living organisms and the metabolism of cells. [0003] In recent years, temperature measurement methods based on the magnetic-temperat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055A61B5/01
CPCA61B5/015A61B5/055
Inventor 刘文中陈璞贇郭斯琳周铭张朴
Owner HUAZHONG UNIV OF SCI & TECH
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