Temperature and concentration imaging method of magnetic nanoparticles

A magnetic nanoparticle and imaging method technology, which is applied in the field of nanomaterial testing, can solve the problems of low spatial resolution and low precision, and achieve the effect of improving spatial resolution and high accuracy of calculation results
CN110179463AActive Publication Date: 2019-08-30HUAZHONG UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
HUAZHONG UNIV OF SCI & TECH
Publication Date
2019-08-30

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Abstract

The invention discloses a temperature and concentration imaging method of magnetic nanoparticles. The method comprises the steps of generating zero magnetic field points by using a gradient magnetic field, determining a sample spatial position activating a magnetic resonance signal, controlling the positions of zero magnetic field points of a direct current gradient magnetic field by using step triangular wave driving magnetic fields in different directions, applying a pulse static magnetic field and radio frequency pulse waves, detecting magnetic resonance frequency information of a magneticnanoparticle liquid sample, obtaining concentration information and temperature information of the magnetic nanoparticles by using a relationship between resonance frequencies and magnetisability of the magnetic nanoparticles according to resonance frequencies of a magnetic nano reagent in different spatial positions within an imaging scope, and finally, achieving magnetic nano temperature imaging. The method achieves the temperature imaging through the concentration information and the temperature information of the magnetic nanoparticles obtained by using a nuclear magnetic resonance technology, effectively increases spatial resolution of magnetic nanoparticle imaging and achieves temperature distribution imaging. According to simulation data, the spatial resolution of the magnetic nanoimaging can be increased and the temperature imaging can be achieved by using the magnetic resonance frequencies for the temperature imaging.
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Description

technical field

[0001] The invention relates to the technical field of nanometer material testing, in particular to a temperature and concentration imaging method of magnetic nanoparticles. Background technique

[0002] Tumor hyperthermia guided by magnetic resonance temperature imaging technology, as a combination of tumor hyperthermia technology and non-invasive thermometry technology, is the focus of clinical tumor physiotherapy research. Compared with other non-invasive temperature measurement methods, magnetic resonance temperature imaging technology will not cause harm to the human body, and can perform imaging at any angle, and can well identify tumors and surrounding tissues. However, the principle of magnetic resonance imaging determines that its measurement results will be affected by factors such as the physiological activities of living organisms and the metabolism of cells.

[0003] In recent years, temperature measurement methods based on the magnetic-temperat...

Claims

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