Thermal stimulus response type medicine releasing nano-carrier based on hollow prussian blue and preparing method of nano-carrier

A Prussian blue and nano-carrier technology, applied in the field of nano-materials, can solve the problems of violent reaction, harmfulness to the human body and the environment, and difficulty in realizing controllable quantitative preparation, etc., and achieve the effect of simple technical operation, cheap raw materials, and universal applicability

Inactive Publication Date: 2019-09-10
WEST CHINA HOSPITAL SICHUAN UNIV
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Problems solved by technology

However, during the acid etching process, this strategy reacts violently and releases toxic substances such as HCN, which is harmful to the human body and the environment, and it is difficult to achieve controllable quantitative preparation

Method used

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  • Thermal stimulus response type medicine releasing nano-carrier based on hollow prussian blue and preparing method of nano-carrier
  • Thermal stimulus response type medicine releasing nano-carrier based on hollow prussian blue and preparing method of nano-carrier

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preparation example Construction

[0023] refer to Figure 1~2 , a method for preparing a thermal stimulus-responsive drug release nanocarrier based on hollow Prussian blue, comprising the following steps:

[0024] Step 1: Dissolve manganese salt in polyvinylpyrrolidone organic solution, add potassium ferricyanide aqueous solution and stir at room temperature to form manganese ferricyanide suspension; the molar ratio of manganese salt to potassium ferricyanide is 3:2-4 : 2; polyvinylpyrrolidone organic solution concentration is 10-30mg / ml;

[0025] Step 2: Add the transition iron salt solution to the manganese ferricyanide suspension, stir and leave it at room temperature to make the manganese ions on the solid surface of manganese ferricyanide react with metal cations with the transition iron ions in the iron salt solution, and the manganese ions It is replaced by transition iron ions; during the reaction process, the manganese ferricyanide that has not participated in the reaction will gradually dissolve to ...

Embodiment

[0036] Step 1, solution preparation: 0.35g polyvinylpyrrolidone is dissolved in 10ml absolute ethanol; Weigh 100mg manganese acetate (MnOAc 3) powder was evenly dissolved in 10ml deionized water. The manganese acetate solution was slowly added to the polyvinylpyrrolidone organic solution and continued to stir for 30 minutes, and then 10ml of 0.03M potassium ferricyanide aqueous solution was added dropwise. After continuous stirring at room temperature for 15 hours, a suspension of manganese ferricyanide can be obtained.

[0037] Step 2, preparation of Prussian blue with nano hollow structure: Fe(NO 3 ) 2 The aqueous solution was added dropwise to the above suspension, stirred rapidly for 10 min and then left at room temperature for 15 h to allow sufficient cation exchange reaction. Centrifuge with deionized water at a rate of 6000 r / min, and dry the obtained precipitate in an oven at 80° C. for 18 hours to obtain a nano-hollow Prussian blue material.

[0038] Step 3, mixin...

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Abstract

The invention discloses a thermal stimulus response type medicine releasing nano-carrier based on hollow prussian blue and a preparing method of the nano-carrier. The preparing method includes the following steps of dissolving manganese salt to form manganese hexacyanoferrate suspension liquid, adding a transition ferric salt solution to the manganese hexacyanoferrate suspension liquid to obtain the prussian blue of a nanometer hollow structure, dissolving a thermo-sensitive material and a medicine in an organic solvent to obtain a mixed solution, dispersing prussian blue particles of the nanometer hollow structure in the same organic solvent to obtain nanoparticle resuspending liquid, injecting the organic solvent in which the thermo-sensitive material and the medicine are dissolved intohollow parts of the prussian blue particles of the nanometer hollow structure, and solidifying the thermo-sensitive material in the medicine-carrying nano-carrier. The thermal stimulus response type medicine releasing nano-carrier based on hollow prussian blue and prepared through the method has the advantages of being simple in operation, mild in reaction condition and low in applied raw materialprice and has universality to preparing the prussian blue of the nanometer hollow structure, and the adopted raw materials are safe, free of toxin and suitable for the field of food medicines.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a thermal stimulus-responsive drug release nanocarrier and a preparation method thereof. Background technique [0002] In cancer treatment, chemotherapy is one of the important means of clinical treatment of cancer, and chemotherapy drugs, due to their own cytotoxicity, kill cancer cells while bringing huge side effects to patients, and are often systemic toxicity. side effect. Stimulus-responsive release is a solution that can reduce toxic side effects and improve drug utilization. With the continuous advancement of drug nanocarrier research, stimuli-responsive drug-releasing nanocarriers have gradually become the focus of researchers. Stimulus-responsive drug-releasing nanocarriers are synthesized using one or more biocompatible materials that undergo specific exogenous or endogenous stimuli such as protonation, hydrolysis, supramolecular conformation change...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/10A61K47/02
CPCA61K9/5115A61K9/5123
Inventor 范让让
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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