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Preparation process for high-purity pralatrexate intermediate

A preparation technology of pralatrexate, which is applied in the field of preparation technology of high-purity pralatrexate intermediates, can solve the problems of high production cost, and achieve the effects of simple structure, accelerated cooling, and improved automation

Inactive Publication Date: 2019-09-13
嘉兴冷暮熙贸易有限公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0004] The technical problem to be solved in the present invention is to provide a preparation process of high-purity pralatrexate intermediate, overcome the problems of low work efficiency and high production cost, improve work efficiency and reduce production cost

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  • Preparation process for high-purity pralatrexate intermediate
  • Preparation process for high-purity pralatrexate intermediate
  • Preparation process for high-purity pralatrexate intermediate

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Embodiment Construction

[0017] Combine below Figure 1-5 The present invention is described in detail, wherein, for the convenience of description, the orientations mentioned below are defined as follows: figure 1 The up, down, left, right, front and back directions of the projection relationship itself are the same.

[0018] combined with Figure 1-5 The mechanical structure diagram of the preparation process of a high-purity pralatrexate intermediate mainly includes a purification box 1, and a drive chamber 61 is provided in the purification box 1, and a motor 46 and a motor 46 are arranged in the drive chamber 61. The motor 46 is connected to the drive shaft 11, and the purification box 1 is provided with a driving mechanism 78 that provides power for the operation of the device. The purification box 1 is also provided with a dissolution chamber 10 and a crystallization chamber 17. The dissolution chamber 10 and the lower end wall of the crystallization chamber 17 are provided with a filter mecha...

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Abstract

The invention discloses a preparation process for a high-purity pralatrexate intermediate. A purification tank is used in the process; a driving chamber is arranged in the purification tank, and the purification tank is internally provided with a driving mechanism for powering the operation of a device used in the process; a dissolution chamber and a crystallization chamber are also arranged in the purification tank; the lower end walls of the dissolution chamber and the crystallization chamber are both internally provided with filtering mechanisms; an air inlet mechanism is arranged in the right end wall of the crystallization chamber; the driving chamber is internally provided with a control mechanism for controlling the operation of the filtering mechanism and the air inlet mechanism. When the device is used for purification of a pralatrexate intermediate, the cooling of a dissolved solution is accelerated in the manners of rotary stirring, bubble stirring and acceleration of gas flow in the crystallization chamber, so the precipitation of crystals in the dissolved solution is accelerated, which thus accelerates purification efficiency; the device carries out both dissolving andcrystallization, so the degree of automation is increased; and dissolving is accelerated by mechanical transmission.

Description

technical field [0001] The invention relates to the field of purification, in particular to a preparation process of a high-purity pralatrexate intermediate. Background technique [0002] When the pralatrexate intermediate is produced, the purity is not high, and crystallization and purification are required again to obtain a high-purity pralatrexate intermediate; [0003] At present, when purifying pralatrexate, the two processes of dissolving coarse crystals and crystallization are mostly carried out step by step, which requires more equipment and increases production costs, and most of them require manual operation, which reduces work efficiency and is not conducive to rapid Production purification. Contents of the invention [0004] The technical problem to be solved by the present invention is to provide a preparation process of a high-purity pralatrexate intermediate, overcome the problems of low work efficiency and high production cost, improve work efficiency and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D9/02
CPCB01D9/0004
Inventor 陆海峰
Owner 嘉兴冷暮熙贸易有限公司
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