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Composite specific yolk antibody oral cavity pressurized spray and preparation method thereof

An oral spray, egg yolk antibody technology, applied in the direction of antibodies, aerosol delivery, antibacterial drugs, etc., can solve problems such as difficulty in maintaining consistent spray volume, irritation of oral mucosa, and imbalance of oral flora, so as to avoid impact. , The effect of reducing production costs and reducing throughput

Active Publication Date: 2019-09-17
GUILIN SANJIN PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Because the way of brushing teeth to clean the oral cavity is cumbersome and difficult to use, there have been products for cleaning the oral cavity such as mouthwash and oral sprays improved by mouthwash. Bacteria or antibiotics are the main active ingredients, and the bacteria in the oral cavity are eliminated through the bactericidal and antibacterial effects of broad-spectrum anti-bacteria and antibiotics. Kill all kinds of bacteria (including beneficial bacteria) in the oral cavity, long-term use will also lead to oral flora imbalance and other oral problems
In addition, through the investigation of oral sprays on the market, we found that most of the nozzles of oral sprays on the market are relatively low-end, it is difficult to maintain consistent spray volume, and the atomization effect is poor. Moreover, most oral sprays contain alcohol, which is harmful to the oral cavity. mucous membrane irritation

Method used

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  • Composite specific yolk antibody oral cavity pressurized spray and preparation method thereof
  • Composite specific yolk antibody oral cavity pressurized spray and preparation method thereof
  • Composite specific yolk antibody oral cavity pressurized spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Take the preparation of 100g egg yolk antibody oral spray as an example:

[0086] (1) Weigh 20 mg of egg yolk antibody powder with a titer of 5120 and 40 mg of cetylpyridinium chloride powder, dissolve them in an appropriate amount of pure water, add pure water after fully dissolving to a weight of 10 g, and prepare a specific composite egg yolk antibody mother solution A;

[0087](2) Take by weighing 0.5g hydrogenated castor oil in a container, simultaneously weigh 0.01g each of borneol and menthol for subsequent use, place the hydrogenated castor oil on a stirrer at 1400 rpm and stir, slowly add the weighed borneol and Menthol, until borneol and menthol are completely dissolved in hydrogenated castor oil, prepared as solution B;

[0088] (3) Weigh 1g of sorbitol, 0.005g of sucralose, and 0.01g of watermelon cream, dissolve them in an appropriate amount of pure water, and prepare solution C;

[0089] (4) Weigh 1g of specific composite egg yolk antibody mother solution...

Embodiment 2

[0092] Take the preparation of 200g egg yolk antibody oral spray as an example:

[0093] (1) Weigh 40 mg of egg yolk antibody powder with a titer of 5120 and 200 mg of cetylpyridinium chloride powder, dissolve them in an appropriate amount of pure water, add pure water after fully dissolving to a weight of 20 g, and prepare a specific composite egg yolk antibody mother solution A;

[0094] (2) Weigh 6g of hydrogenated castor oil in a container, simultaneously weigh 0.1g each of borneol and menthol for later use, place the hydrogenated castor oil on a stirrer at 1600 rpm and stir, slowly add the weighed borneol and mint Alcohol until borneol and menthol are completely dissolved in hydrogenated castor oil to prepare solution B;

[0095] (3) Weigh 20g of sorbitol, 0.1g of sucralose, and 0.2g of watermelon frost, dissolve them in an appropriate amount of pure water, and prepare solution C;

[0096] (4) Weigh 20g of specific composite egg yolk antibody mother solution A, add solut...

Embodiment 3

[0099] Preparation of complex-specific yolk antibody against Porphyromonas gingivalis and Actinobacillus actinomycetes:

[0100] A. Cultivate and extract Porphyromonas gingivalis and Actinobacillus actinomycetes:

[0101] Porphyromonas gingivalis (P.g) ATCC33277 strain and Actinobacillus actinomycetes (A.a) ATCC29523 strain from Guangdong Microbial Culture Collection Center were amplified and cultured on blood agar plate medium and identified by Gram staining . Porphyromonas gingivalis (P.g) ATCC33277 strain was cultured for 3 days, and Actinobacillus actinomyces (A.a) ATCC29523 strain was cultured for 1 day, and the bacteria were scraped in PBS buffer solution with an inoculation loop. Repeat the centrifugation and extraction three times, and collect the bacterial cell pellet, which is the desired bacterial cell.

[0102] B. Preparation of immunogen:

[0103] B1. Take Porphyromonas gingivalis and Actinobacillus actinomycetes respectively, and adjust the colony density to 3...

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Abstract

The invention discloses a composite specific yolk antibody oral cavity pressurized spray and a preparation method thereof. The oral cavity pressurized spray consists of the following components of composite specific yolk antibodies resisting porphyromonas gingivalis and actinobacillus actinomycetemcomitans, sorbitol, hydrogenated castor oil, sucralose, borneol, menthol, mirabilitum praeparatum and pure water. The oral cavity pressurized spray disclosed by the invention is simple and safe in components, free from toxic and side effects, free from alcohol, mild and free from irritating, has good bacteriostasis effects on specific bacteria of the porphyromonas gingivalis and the actinobacillus actinomycetemcomitans, can effectively restrain the bacteria from forming biomembranes, can reduce production and development of dental plaques, has good prevention effects on gingivitis and periodontitis, is simple, convenient and practical in preparation, low in production cost and good in product stability.

Description

technical field [0001] The invention belongs to the field of daily chemical disinfection products, in particular, relates to a composite specific egg yolk antibody oral spray and a preparation method thereof, more specifically, relates to anti-Porphyromonas gingivalis and Actinobacillus actinomycetes specificity Egg yolk antibody oral spray and preparation method thereof. Background technique [0002] The oral cavity is an important part of the human respiratory system and digestive system. Oral health is of great significance to human health. However, with the acceleration of people's life rhythm, people have less and less time for oral cleaning and health care, which directly leads to the current Most people are more or less troubled by oral diseases in varying degrees. Scientific research shows that oral diseases such as periodontitis, gingivitis, dental caries, bad breath, etc. are all caused by the excessive proliferation of oral pathogenic bacteria and the imbalance o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/40A61K9/12A61K47/44A61K47/26A61K47/10A61K47/22A61P1/02A61P31/04
CPCA61K39/40A61K9/006A61K47/44A61K47/26A61K47/10A61K47/22A61P1/02A61P31/04A61K9/12Y02A50/30
Inventor 邹节明贾成刚
Owner GUILIN SANJIN PHARMACEUTICALS CO LTD
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