Application of Cystatin SN in forecast of sensitivity of chronic rhinosinusitis with polyposis patient on glucocorticoid

A technology for glucocorticoids and chronic sinusitis, applied in the application field of sensitivity, can solve problems such as increased diagnosis and treatment costs, achieve good prediction performance, simple and fast detection methods, and good clinical application prospects

Active Publication Date: 2019-09-17
BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
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Problems solved by technology

Although short-term or local use of glucocorticoids has almost no systemic side effects of glucocorticoids, it still brings increased medical costs for patients who are not sensitive to glucocorticoids

Method used

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  • Application of Cystatin SN in forecast of sensitivity of chronic rhinosinusitis with polyposis patient on glucocorticoid
  • Application of Cystatin SN in forecast of sensitivity of chronic rhinosinusitis with polyposis patient on glucocorticoid
  • Application of Cystatin SN in forecast of sensitivity of chronic rhinosinusitis with polyposis patient on glucocorticoid

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Embodiment

[0045] 1. Research Methods

[0046] 1. Patient enrollment and hormone sensitivity evaluation indicators:

[0047] Patients with chronic sinusitis with nasal polyps were enrolled: patients with chronic sinusitis who met the EPOS 2012 diagnostic criteria and had no contraindications to oral glucocorticoids, collected clinical information (sex, age, concomitant diseases, symptom scores, sinus CT Lund-Mackay score , polyp size score before hormone therapy, etc.).

[0048] Each patient received 2 weeks of oral hormone therapy (methylprednisolone 24mg, taken in the morning, and took it in the morning), and the polyp size score was performed again after the oral hormone therapy. According to the changes in polyp score before and after oral hormone therapy, the patients were divided into hormone-sensitive groups ( polyp size score decreased by more than 1 point) and hormone insensitive group (polyp size score decreased by no more than 1 point). The scoring criteria are as follows: ...

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Abstract

The invention relates to the field of molecular biological detection, in particular to application of Cystatin SN in forecast of sensitivity of a chronic rhinosinusitis with polyposis patient on glucocorticoid. A sample collection method of a forecast method is safe and non-invasive, is good in tolerance, simple and rapid in detection method and favorable in forecast performance and has favorable clinical application prospect.

Description

technical field [0001] The invention relates to the field of molecular biology detection, in particular to the application of Cystatin SN in predicting the sensitivity of chronic sinusitis patients with nasal polyps to glucocorticoids. Background technique [0002] Chronic sinusitis with nasal polyps, with a population of more than 80 million in my country, is a common and intractable disease of the nose. It is related to various chronic diseases (such as heart disease, hypertension, etc.) and even mental diseases, seriously endangering the health of patients. At the same time, it brings a heavy burden to the national medical expenditure. But its therapeutic effect is still unsatisfactory. Under the medical background of "emphasizing prevention, early intervention, and comprehensive treatment", it is inevitable for the future development of disciplines to guide clinical practice through scientific research results and provide patients with accurate, effective, safe, and econ...

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Application Information

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IPC IPC(8): G01N33/74
CPCG01N33/74
Inventor 张罗王成硕闫冰
Owner BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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