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Modeling method of Bama miniature pig excess heat syndrome model

A technology of Bama miniature pigs and excess heat syndrome, which is applied in the fields of medical science, veterinary instruments, veterinary surgery, etc., and can solve the problems that animal models have not been reported.

Inactive Publication Date: 2019-09-20
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on the establishment of TCM syndrome models is still in its infancy, and there are no reports on animal models of excess heat syndrome

Method used

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  • Modeling method of Bama miniature pig excess heat syndrome model
  • Modeling method of Bama miniature pig excess heat syndrome model
  • Modeling method of Bama miniature pig excess heat syndrome model

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Example 1: Modeling method of Bama miniature pig animal model of excess heat syndrome

[0026] Modeling method of the present invention comprises the steps:

[0027] A total of 12 pigs with an average age of 2±1 months and an average weight of 4-7 kg were selected, and the Bama miniature pigs were randomly divided into a control group and a model group (excessive heat group), with 6 pigs in each group. All animals were fed normally in independent cages without any special treatment for 7 consecutive days. On the 8th day, before the modeling, the piglets of the two groups were fasted for 10 hours, and the endotoxin was dissolved in 5ml~10ml of normal saline at a dose of 1mg / kg, and the intramuscular injection was carried out; the control group was injected with the same dose of saline.

Embodiment 2

[0028] Embodiment 2: Modeling method of Bama miniature pig animal model of excess heat syndrome

[0029] Modeling method of the present invention comprises the steps:

[0030] A total of 12 pigs with an average age of 2±1 months and an average weight of 4-7 kg were selected, and the Bama miniature pigs were randomly divided into a control group and a model group (excessive heat group), with 6 pigs in each group. All animals were fed normally in independent cages without any special treatment for 7 consecutive days. On the 8th day, before the modeling, the piglets of the two groups were fasted for 8 hours, and the endotoxin was dissolved in 5ml-10ml of normal saline at a dose of 0.6mg / kg, and the intramuscular injection was carried out; the control group was injected with same dose of normal saline.

Embodiment 3

[0031] Example 3: Modeling method of Bama miniature pig animal model of excess heat syndrome

[0032] Modeling method of the present invention comprises the steps:

[0033] A total of 12 pigs with an average age of 2±1 months and an average weight of 4-7 kg were selected, and the Bama miniature pigs were randomly divided into a control group and a model group (excessive heat group), with 6 pigs in each group. All animals were fed normally in independent cages without any special treatment for 7 consecutive days. On the 8th day, before the modeling, the piglets of the two groups were fasted for 10 hours, and the endotoxin was taken and dissolved in 5ml-10ml of normal saline at a dose of 1.5mg / kg, and the intramuscular injection was carried out; the control group was injected with same dose of normal saline.

[0034] The beneficial effects of the present invention will be further described in the form of experimental examples below.

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Abstract

The invention discloses a modeling method of a Bama miniature pig excess heat syndrome model. A Bama miniature pig is taken as an experimental animal to manufacture the excess heat syndrome model by intramuscular injection of endotoxin. The method is simple to operate, high in modeling success rate and easy to popularize and apply, the animal model of the excess heat syndrome of the traditional Chinese medicine can be improved, objective reference standards are provided for syndrome differentiation and treatment and quantitative identification of the syndrome, and the modernization development of the animal model of the syndrome of the traditional Chinese medicine is promoted.

Description

technical field [0001] The invention relates to a modeling method of an animal model, in particular to a modeling method of a Bama miniature pig model of excess heat syndrome. Background technique [0002] Excess Heat Syndrome is a syndrome name in TCM theory, which is a syndrome of exuberance of pathogenic heat and internal and external excess. Due to the invasion of heat evil, the internal heat is blazing, or it is caused by phlegm and blood stasis, and stagnation of food. Symptoms include strong heat and irritability, red face and red eyes, thirst for cold drinks, chest pain with yellow sputum, abdominal pain and refusal to press, constipation, short red urine, red tongue with yellow coating, rapid and slippery pulse, etc. [0003] Animal models are important tools in medical research. At present, there are many animal models in Western medicine research, such as inflammation models, tumor models and so on. However, the establishment of TCM syndrome models is still in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 路雪婧肖建强陈斐斐赵丽峰宋姗姗相波余丰尹硕
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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