Application of EBV (Epstein-Barr virus) BRLF1 and its functional small peptide in inhibiting activity of inflammasomes

An inflammasome and functional technology, applied in the direction of peptides, allergic diseases, peptide/protein components, etc., can solve the problems of unclear activation and regulation mechanisms, achieve good penetration, and inhibit the activity of inflammasomes Effect

Active Publication Date: 2019-09-20
SUN YAT SEN UNIV
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Problems solved by technology

[0007] Although the research on inflammasome has made great progress in the past ten years, its specific activation and regulation mechanism is still not very clear. There are still some questions about the mechanism of inflammasome induction and inhibition in herpes virus, especially EBV virus infection. much to be studied

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  • Application of EBV (Epstein-Barr virus) BRLF1 and its functional small peptide in inhibiting activity of inflammasomes
  • Application of EBV (Epstein-Barr virus) BRLF1 and its functional small peptide in inhibiting activity of inflammasomes
  • Application of EBV (Epstein-Barr virus) BRLF1 and its functional small peptide in inhibiting activity of inflammasomes

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[0030] The technical solution of the present invention will be further described below in combination with experiments.

[0031] Unless otherwise specified, the reagents, equipment and methods used in the present invention are commercially available reagents, equipment and routinely used methods in this technical field.

[0032] As a gamma-herpes virus, EBV has a life cycle that is divided into a latent period and a lytic period. After a short acute response, the cells enter the latent period quickly after being infected. In the host cell, the EBV viral genome can continuously activate the host's inflammasome system, enabling cells to maintain a certain level of inflammasome activation. As another type of human herpes virus, HSV-1 mainly performs infection and replication during the lytic phase, and can rapidly activate a series of inflammasome systems through its viral genome and viral proteins after infecting cells. Therefore, detection of inflammasome activity activated by...

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Abstract

The invention discloses application of BRLF1 in the preparation of preparations to inhibit activity of Herpes virus-activated inflammasomes, and also discloses a BRLF1 functional small peptide which may act on inflammasome activity pathways and has a broad-spectrum inhibitory function for the activity of inflammasomes. After a small peptide is conjugated with and passed through a signal peptide, good penetrating property is provided; the functional small peptide can enter cells directly to better give rise to the effect of inhibiting the activity of inflammasomes.

Description

technical field [0001] The invention relates to the application of EBV BRLF1 and its functional small peptides in inhibiting the activity of inflammasomes. Background technique [0002] Herpesviruses (Herpesviruses) are a class of medium-sized double-stranded DNA viruses with more than 100 members. They are widely distributed in nature and can infect amphibians (frogs), birds (chickens), mammals (rabbits, horses, cattle, pigs, cats), but also primates (monkeys) and humans. According to their physical and chemical properties, they are divided into three subfamilies α, β, and γ. Alphaherpes viruses (such as herpes simplex virus, varicella-zoster virus) multiply rapidly and cause cytopathic changes. Beta herpes viruses (such as cytomegalovirus) have a long growth cycle and infect cells to form giant cells. Gamma herpes virus (such as Epstein-Barr virus), the target cell of infection is lymphoid cell, can cause lymphoid hyperplasia. Herpesviruses infect a wide range of hosts...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K47/64A61P37/06C07K7/06
CPCA61K38/08A61K47/64A61P37/06C07K7/06
Inventor 况二胜龙徐兵
Owner SUN YAT SEN UNIV
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