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Acidic pseudo-ginseng polysaccharide and extraction-purification method thereof

A technology of Panax notoginseng polysaccharide and purification method, applied in the field of medicine, can solve problems such as unidentified polysaccharide components and structural composition, and achieve the effect of protection effect

Active Publication Date: 2019-09-20
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The residue of Panax notoginseng is discarded after extraction, and about 300,000 to 500,000 tons of Panax notoginseng polysaccharide has not been effectively utilized
However, this patent did not further separate and purify the polysaccharide extract, nor did it identify the polysaccharide components and structural composition

Method used

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  • Acidic pseudo-ginseng polysaccharide and extraction-purification method thereof
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  • Acidic pseudo-ginseng polysaccharide and extraction-purification method thereof

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Embodiment 1

[0021] Extraction and purification of notoginseng acidic polysaccharide:

[0022] (1) Dry the Panax notoginseng medicinal residue after extracting the total saponins of Panax notoginseng at 50°C, crush it and pass it through an 80-mesh sieve, add 20 times the volume of distilled water, extract at 70°C for 4 hours, filter, collect the residue, and then Add 15 times the volume of distilled water, repeat the extraction for 4 hours, filter, and combine the two extracts; refer to the sevag method (sevag solution is chloroform: n-butanol (V:V) = 5:1) for deproteinization treatment, that is, add the extract 0.3 times the volume of sevag solution, shake vigorously for 15 minutes, wait for static layering, separate the protein layer, repeat four times until the protein is completely removed, put the extract at 50 °C and concentrate it to 1 / 6 of the original volume by rotary evaporation. Add 3 times the volume of absolute ethanol, precipitate out, remove ethanol in a 55°C water bath, re...

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Abstract

The invention discloses an acidic pseudo-ginseng polysaccharide and an extraction-purification method thereof. The molecular weight of the acidic pseudo-ginseng polysaccharide is 2500-3000 kDa; the acidic pseudo-ginseng polysaccharide is composed of following mono-saccharides: Rha, Ara, Man, Glc, Gal, and GalA according to a mole ratio of 0.038: 0.045: 0.002: 0.016: 0.031: 0.868; and GalA is galacturonic acid, which has following types of glycosidic bonds: Ara-1<arrow>, Rha-1<arrow>, <arrow>5-Ara-1<arrow>, <arrow>4-GalA-1<arrow>, and <arrow>3,6-Gal-1<arrow> according to a ratio of 0.06:0.04:0.80:0.05. After total saponins are extracted, the residues of pseudo-ginseng are re-extracted to obtain the acidic pseudo-ginseng polysaccharide; the pharmaceutical value of pseudo-ginseng is fully utilized, pseudo-ginseng is better utilized, the method has an important meaning for secondary development of pseudo-ginseng; and the extracted acidic pseudo-ginseng polysaccharide can obviously relieve alcoholic liver injury.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an acidic notoginseng polysaccharide and an extraction and purification method thereof. Background technique [0002] Polysaccharides are widely found in animals, plants and microorganisms. As one of the components of living matter, polysaccharides are widely involved in the regulation of various life phenomena and physiological processes of cells. Its physiological activities include anti-oxidation, anti-tumor, hypolipidemic, antibacterial, etc. The biological activity of polysaccharides is closely related to its structural composition and spatial conformation. It is of great significance to study the structure and composition of polysaccharides for their development and utilization. [0003] Panax notoginseng is a perennial herb of Araliaceae ginseng. It is a precious medicinal material in my country. Panax notoginseng saponins are active ingredients in the prevention and treatment of...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61P1/16A61P25/32
CPCC08B37/006C08B37/0003A61P1/16A61P25/32
Inventor 崔秀明刘胜男王承潇杨野杨晓艳曲媛刘迪秋
Owner KUNMING UNIV OF SCI & TECH
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