Method and device for non-mark all-optical nerve regulation and imaging

An all-optical neural and imaging device technology, used in the field of biomedical imaging

Active Publication Date: 2019-10-01
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, current methods cannot simultaneously be non-contact (no insertion or application of any material), large...

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  • Method and device for non-mark all-optical nerve regulation and imaging
  • Method and device for non-mark all-optical nerve regulation and imaging
  • Method and device for non-mark all-optical nerve regulation and imaging

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Embodiment Construction

[0050] Specific embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings, which form a part of this document. It should be noted that these descriptions and examples are illustrative only, and should not be construed as limiting the scope of the present invention. The protection scope of the present invention is defined by the appended claims, and any changes based on the claims of the present invention All are protection scope of the present invention.

[0051] In order to facilitate the understanding of the embodiments of the present invention, each operation is described as a plurality of discrete operations, however, the order of description does not represent the order in which the operations are performed.

[0052] In this description, the x-y-z three-dimensional coordinate representation based on the spatial direction is used for the sample measurement space. This description is provided merely to facilitate d...

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Abstract

The invention discloses a method and device for non-mark all-optical nerve regulation and imaging. Infrared laser pulses are used for stimulating nerve activity, OCT is used for collecting optical scattered signals triggered by nerve activity, and therefore non-mark all-optical nerve regulation and imaging are realized. The method includes the detailed steps that infrared lasers aim at a brain target region, laser pulses of a certain time sequence are injected, OCT is used for conducting synchronous scanning imaging on the target region, relative changes of the OCT scattered signals are analyzed compared with the conditions prior to laser stimulation, brain function signals based on OCT are obtained, and therefore nerve regulation and imaging are realized synchronously. Nerve regulation and imaging can be developed synchronously, crosstalk of a regulation/imaging channel is avoided, a contrast medium and virus transfection are not needed, and regulation and imaging of tissue deep regions can be realized through near infrared bands.

Description

technical field [0001] The invention belongs to the field of biomedical imaging, relates to optical coherence tomography (Optical Coherence Tomography, OCT) and neuromodulation technology, in particular to a label-free all-optical neuromodulation and imaging method and device based on the principle of low coherence interference, which can be used In basic and applied neuroscience research, study the response and mapping of biological cortical neurons stimulated by near-infrared pulses. [0002] technical background [0003] The brain is the core of the life movement of organisms and the focus of scientists' research. When the brain is exposed to external stimuli, it will produce changes in functional signals, which are closely related to biological functions. Therefore, it is of great significance for the pathological research of human diseases to be able to realize neural regulation and imaging, and to accurately analyze the changes of neural function signals. [0004] For...

Claims

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Application Information

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IPC IPC(8): A61B5/00A61N5/067A61N5/06
CPCA61B5/0066A61B5/0075A61B5/4064A61N5/0622A61N2005/0659A61N2005/0626A61N5/067A61B5/0261A61B3/102G01B9/0209G01N21/47
Inventor 李鹏姚霖
Owner ZHEJIANG UNIV
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