The invention discloses an intelligent management method of unmanned pipeline traffic, and relates to a rail traffic management method. The method includes the steps of building closed pipelines, setting up a plurality of stations, placing rail vehicles, setting up stations, connecting a plurality of rail vehicles in the closed pipelines into a whole through a large data controller, inputting a starting station and a destination station by passengers, determining the vehicle running route and the optimal running speed, and transporting the passengers to the destination station by the rail vehicles according to the received vehicle running route and running speed. According to the method, the rail vehicles are placed in the closed pipelines, the interconnection of all the rail vehicles is realized through a large data technology, all the rail vehicles are formed into a whole, unmanned driving is realized under the unified computing environment of computers, mutual non-interference of the rail vehicles in the closed pipeline can be ensured, and passengers can reach the destination station with a best route and speed.