Application of hydrogen-rich water composition in inhibiting endoplasmic reticulum stress and autophagy induced by hexavalent chromium in df-1 cells

Abstract

The invention discloses the application of a hydrogen-rich water composition in inhibiting endoplasmic reticulum stress and autophagy of DF-1 cells induced by hexavalent chromium, the hydrogen-rich water composition contains: H 2 0.6mM-1.1mM, sodium alginate 1.8-2.4g / L, mannan 1.2-1.6g / L; the hydrogen-rich water composition of the present invention can maintain the stability of the hydrogen content in the hydrogen-rich water; The hydrogen water composition can inhibit the Cr(VI)-induced increase in the expression of COX-2 in DF-1 cells, thereby inhibiting the endoplasmic reticulum stress and excessive autophagy in DF-1 cells caused by the increase of COX-2 .

Description

technical field [0001] The invention relates to the technical field of medical applications of hydrogen-rich water compositions, in particular to the application of hydrogen-rich water compositions in inhibiting DF-1 cell endoplasmic reticulum stress and autophagy induced by hexavalent chromium. Background technique [0002] The endoplasmic reticulum (ER) is a precise membrane system in living cells, widely present in eukaryotic cells, involved in protein folding and maintaining calcium homeostasis. Efficient ER function is essential for normal cellular activity. When ER function is disturbed by some internal or external stimuli such as ischemia hypoxia, nutritional deficiency, homocysteine, etc., the endoplasmic reticulum cannot perform normal physiological functions. When endoplasmic reticulum stress occurs, unfolded or misfolded proteins will accumulate, and when these proteins accumulate to a certain extent, they will give a feedback signal to the endoplasmic reticulum,...

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Problems solved by technology

However, there is still a lack of relevant research on how to inhibit the increase of COX-2 in DF-1 cells caused by hexavalent chromium, and the endoplasmic reticulum stress and excessive autophagy in DF-1 cells caused by the increase of COX-2

However, there are no reports about hydrogen-rich water inhibiting the increase of COX-2 in DF-1 cells caused by hexavalent chromium, and the endoplasmic reticulum stress and excessive autophagy of DF-1 cells caused by the increase of COX-2

[0006] Moreover, due to the small molecular weight of hydrogen and other reasons, hydrogen permeability is extremely strong. Therefore, hydrogen is very easy to diffuse through packaging materials and tiny gaps, so that the hydrogen content in hydrogen-rich products is reduced, or even does not contain hydrogen, giving hydrogen-rich products The storage and transportation bring great difficulties, which limits the popularization and application of hydrogen-rich products

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