Compound composition and pharmaceutical composition and application thereof

Abstract

The invention discloses a compound composition and a pharmaceutical composition and application thereof. The compound composition comprises 30-50 parts of acetaminophen and 50-70 parts of naproxen aseffective components. The compound composition and the pharmaceutical composition, through the combined use of paracetamol and naproxen in an effective mass ratio, exhibit significant anti-pain advantages in dissolution in vitro and in animal pain models; the dissolution rates of PAR and NAP in the compound composition and the pharmaceutical composition are higher than those of PAR and NAP used alone, thus in the composition of a prescription, the dosages of the active ingredients can be reduced and the therapeutic equivalence can be achieved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound composition and its pharmaceutical composition and application. Background technique [0002] Migraine is a recurrent pulsating headache and a common disease. Before the attack, there are often auras such as flashing lights, blurred vision, and numbness of the limbs. It takes about a few minutes to an hour for one side of the head to jump and jump. Pain, and gradually intensified, until nausea, vomiting, feeling will be better, in a quiet, dark environment or after sleep headache relief. It may be accompanied by neurological and mental dysfunction before or during the onset of headache. At the same time, it is a progressive disease, often with increasing frequency. Migraine sufferers are more likely than the general population to develop localized damage to the brain that can lead to strokes, according to research. The more migraines they had, the larger the area of ​​the br...

AI Technical Summary

Problems solved by technology

For patients who cannot tolerate anti-inflammatory and analgesic drugs such as aspirin and indomethacin due to anemia, gastrointestinal system diseases or other reasons, this product can obtain satisfactory results, and at the same time, the effect of inhibiting platelets is small, but due to the therapeutic mechanism of the above-mentioned single preparation Single, the clinical effect is not satisfactory, and more effective migraine drugs need to be found

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