Blood amiodarone drug concentration monitoring kit and detection method thereof

An amiodarone and kit technology, which is applied to the field of amiodarone therapeutic drug monitoring kits in blood, can solve the problems of high technical requirements for experimenters, inaccurate qualitative and quantitative analysis, long analysis time, etc., so as to reduce errors and personnel operations. The effect of error, simple and fast detection process, and reduced experimental cost

Inactive Publication Date: 2019-10-22
苏州艾迪迈医疗科技有限公司
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Problems solved by technology

Previous methods have problems such as complicated pre-treatment, inaccurate qualitative and quan

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  • Blood amiodarone drug concentration monitoring kit and detection method thereof
  • Blood amiodarone drug concentration monitoring kit and detection method thereof
  • Blood amiodarone drug concentration monitoring kit and detection method thereof

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Embodiment Construction

[0035] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further elaborated below in conjunction with illustrations and specific embodiments.

[0036] One, the preparation of amiodarone therapeutic drug monitoring kit:

[0037] Standard curve reagents: amiodarone is prepared into a series of concentrations with animal serum containing 2% stabilizer and 2% plasticizer, respectively 0.4mg / L, 1.0mg / L, 2.0mg / L, 4.0mg / L, 6.0mg / L, 10.0mg / L, 1.0ml per bottle. The above components were freeze-dried and stored at the bottom of the assay bottle.

[0038] Quality control reagent: amiodarone is formulated with animal serum containing 2% stabilizer and 2% plasticizer to three concentrations of high, medium and low, respectively 0.5mg / L, 3.5mg / L, and 8.0mg / L. The bottle is filled with 1.0ml. The above components were freeze-dried and stored at the bottom of the assay bottle.

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Abstract

The invention relates to the field of medical detection and in particular to a blood amiodarone therapeutic drug monitoring kit developed based on multi-dimensional online solid-phase extraction liquid chromatography analytical technology, more specifically to a method for accurately and quantitatively detecting amiodarone drug concentration in blood by online solid-phase extraction and multi-dimensional liquid chromatography analytical technology. The kit includes a calibration reagent, a quality control reagent, a processing liquid, an extract liquid, a washing liquid, and an eluent. The therapeutic drug monitoring kit of the invention only needs to centrifuge a blood sample, achieves low repeated detection variability, high accuracy and stability, and low detection cost, has various methodological indicators that satisfy the requirement for monitoring the blood amiodarone therapeutic drugs, and is easy to generalize.

Description

technical field [0001] The invention relates to the field of medical detection, in particular to a kit for monitoring amiodarone therapeutic drug in blood developed based on multi-dimensional online solid-phase extraction liquid chromatography analysis technology, more specifically, it adopts online solid-phase extraction and multi-dimensional liquid phase Chromatographic analysis technology is a method for accurate and quantitative monitoring of amiodarone drug concentration in blood. Background technique [0002] Amiodarone is a class III antiarrhythmic drug. The main electrophysiological effect is to prolong the action potential and effective refractory period of each myocardial tissue, which is beneficial to eliminate reentrant excitement. At the same time, it has mild non-competitive and adrenergic receptor blockers and mild I and IV antiarrhythmic drug properties. Decreased sinus node automaticity. The effective plasma concentration of amiodarone is 0.92-3.75mg / L, a...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/16G01N30/34G01N30/86
CPCG01N30/06G01N30/16G01N30/34G01N30/8631
Inventor 石功名何伶秀杨凡
Owner 苏州艾迪迈医疗科技有限公司
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