A kind of tensile test method of biological sample

Abstract

The present invention relates to the field of biotechnology research, and relates to a biological sample tensile testing method. The biological sample tensile testing device includes a housing and a driver located in the housing, a movable clamp, a movable arm 1, an adjustment rod 1, a magnet 1, and a vertical clamp I. Vertical fixture II, substrate, movable arm II, adjustment rod II, magnet II, fixed fixture, liquid reservoir, support table, translation stage, microscope, guide rail I and guide rail II, capable of living cells at the subcellular scale In-situ imaging can be dynamically stretched at the same time. Using a special drive mechanism and fixture structure, it can perform in-situ imaging on subcellular-scale biological cell samples while performing uniaxial dynamic stretching, so as to study stretching. The characteristics of the cells after stimulation, and to study the characteristics of the cells through in situ imaging, the substrate is not easy to tear, and the stretching frequency can be adjusted in a large range, and the stretching can be adjusted in a large range.

Description

technical field [0001] The invention relates to the field of biotechnology research, in particular to a biological sample tensile testing method capable of in situ imaging of subcellular scale living cells and capable of simultaneously performing dynamic stretching. Background technique [0002] In the process of tissue development and repair of cells, mechanical stretching can be used as an important means to regulate the state and function of cells. There are many methods to mechanically stimulate cells in the existing technology, but most of them use mechanical driving. The existing technology of the stretching device is not suitable for in situ imaging of living cells at the subcellular scale, and, among the few existing technologies that can perform real-time live cell imaging at the subcellular scale, the dynamic stretching of cells is limited. , and its adjustable frequency range and adjustable stretching amplitude range cannot meet the experimental requirements, and ...

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Problems solved by technology

[0002] In the process of cell tissue development and repair, mechanical stretching can be used as an important means to regulate the state and function of cells. There are many methods in the prior art to mechanically stimulate cells, but most of them use mechanical actuation. The existing technology of stretching device is not suitable for in situ imaging of live cells at the subcellular scale, and among the few existing technologies capable of real-time live cell imaging at the subcellular scale, the dynamic stretching of cells is limited , and its adjustable frequency range and adjustable stretching amplitude range cannot meet the experimental requirements, the biological sample stretching test method can solve the problem

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