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Rapid and controlled delivery of compositions with restored entourage effects

An environmental, fast-acting technology, applied in drug combination, drug delivery, active ingredients of hydroxyl compounds, etc., can solve problems such as cannabinoids lacking phytochemicals that contribute to environmental effects

Inactive Publication Date: 2019-10-25
RECEPTOR HLDG INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Consequently, orally consumed cannabis products and / or cannabinoids often lack phytochemicals that contribute to environmental effects

Method used

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  • Rapid and controlled delivery of compositions with restored entourage effects
  • Rapid and controlled delivery of compositions with restored entourage effects
  • Rapid and controlled delivery of compositions with restored entourage effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0299] Example 1. Oral cannabinoid dosage forms provide improved bioavailability and reduced time to onset of action.

[0300] Given the large number of medical conditions that may benefit from cannabis therapy, there is a significant unmet need for fast-acting products that provide improved bioavailability in oral form. Current oral cannabis products, including edibles and traditional pharmaceutical dosage forms, are challenged by low bioavailability and prolonged onset times. The present disclosure addresses the shortcomings of all existing oral cannabis products to provide improved onset time and improved bioavailability.

[0301] Onset and duration of action of orally administered cannabis / SNAC compositions. This study aimed to assess the utility of SNAC in achieving a fast-acting oral form of cannabis.

[0302] Participant's choice. Six study participants were recruited to ingest cannabis components and the onset, duration and intensity of cannabis-induced euphoria and...

Embodiment 2

[0317] Example 2. Onset and duration of action of orally administered cannabis / SNAC compositions at low SNAC doses. This study aimed to assess the utility of SNAC in achieving a fast-acting oral form of cannabis at low doses.

[0318] Participant's choice. Three study participants were recruited to ingest cannabis components and recorded the onset, duration and intensity of cannabis-induced euphoria and / or dysphoria. Study participants participated in two separate tests: 1) with a control substance, which contained liquid cannabis extract dissolved in aqueous ethanol, and 2) with a test substance, which contained liquid cannabis extract dissolved in aqueous ethanol and SNAC.

[0319] preparation. The selected cannabis concentrate was commercially available and provided to the participants in the form of an ethanol solution. The concentrate contains 8mg THC per dose. It was chosen for its high percentage of THC, which has a noticeable effect on the "euphoria" reported by u...

Embodiment 3

[0328] Embodiment 3. inhalation contrasts with oral group reaction ( Figure 9 ). Euphoria as measured by subject-reported comparison of pharmacodynamic responses to inhaled and oral cannabis. Similar time to peak effect (15-30 minutes) was reported for both oral and inhalation groups. This was very surprising, as oral cannabis has traditionally been characterized by a very slow peak effect (up to 4 hours).

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Abstract

Fast-acting oral formulations with restored entourage effects are described. The formulations include beneficial combinations of plant-derived molecules to provide restored entourage effects, and oneor more carriers. The carriers can include N-acylated fatty amino acids, absorption enhancers, and / or various other beneficial carriers. The fast-acting oral formulations can create administration benefits.

Description

[0001] Cross References to Related Applications [0002] This application claims priority from 62 / 475,763, filed March 23, 2017, the entire contents of which are incorporated herein by reference as if fully set forth herein. technical field [0003] The present disclosure provides fast-acting oral formulations of plant-based compositions with restorative environmental effects. The plant-based composition comprises a combination of beneficial plant-derived molecules to provide a restorative entourage effect. The formulations include one or more carriers that allow for rapid and controlled delivery of the plant-based composition. Carriers may include N-acylated fatty amino acids, absorption enhancers, and / or various other beneficial carriers. Background technique [0004] Historically, the plant world has been the most important source of medicines used to treat human and animal diseases and used as preventives and nutritional supplements to maintain health. However, for at...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/10
CPCA61K9/0053A61K47/10A61K47/18A61K31/05A61K31/352A61P25/00A61K9/0095A61K9/08A61K45/06A23L33/16A23L33/15A23L33/17A61K2300/00A61K47/183A61K36/185A23L33/105A23L33/155A23V2002/00A61K9/0056A61K31/047A61K31/20
Inventor A·莱昂内-贝G·韦斯纳
Owner RECEPTOR HLDG INC