Hydrogel, preparation method thereof and freeze-drying support frame
A hydrogel and freeze-drying technology, which is applied in the field of hydrogel, freeze-dried scaffold, and preparation, can solve the problems of limited application, influence of cell viability state, unsatisfactory hydrogel preparation, etc., and achieves wide application and excellent physical and chemical properties Effect
Pending Publication Date: 2019-11-08
JIANGSU TRAUTEC MEDICAL TECH CO LTD
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Problems solved by technology
[0003] The hydrogel formed by natural materials has poor mechanical properties and fast biodegradation rate, which limits its clinical application. At the same time, there are still some materials derived from animals, which have poor immunogenicity. degree of immune rejection; synthetic materials, although promising in terms of improved mechanical properties, printability, cross-linking, etc., are less effective than natural materials in promoting cell attachment and proliferation
[0004] In addition, there are many kinds of photoinitiators, such as Irgacure 651, Irgacure 2959 and Esoin Y, etc., most of which have problems such as poor water solubility, and use ultraviolet light crosslinking, the crosslinking effect is not ideal under visible light, and ultraviolet light will affect the viability of the cells
The preparation of hydrogel is not ideal, and the application range is limited
Method used
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preparation example Construction
[0044] The preparation method 100 of the hydrogel according to the embodiment of the present invention is as image 3 As shown, it mainly includes the following steps:
[0045] S10. Weighing the grafted product and dissolving it in a DPBS solution of phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt (LAP) to form a solution;
[0046] S20, irradiating the above solution with blue light to form a hydrogel.
[0047] Specifically, lithium phenyl (2,4,6-trimethylbenzoyl) phosphate (LAP) has good water solubility and can undergo cross-linking reaction under visible light. When excited, there is almost no damage to the cells, and the curing time is 1-5s.
[0048] That is to say, through the blue light cross-linking technology, the formed hydrogel has a fast gelation speed and less damage to cells. The preparation process of the hydrogel is as follows figure 1 As shown, the preparation mechanism of the hydrogel is shown in 2. The photopolymerization reaction of the MARHC hydr...
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Abstract
The invention provides a hydrogel, a preparation method thereof and a freeze-drying support frame. The molecular formula of the hydrogel is as the follows. The hydrogel provided by the invention has asimple molecular formula, can be used as a raw material for 3D printing biological ink in the future, and has a good application prospect in the field of tissue repair engineering.
Description
technical field [0001] The invention relates to the technical field of biological hydrogel, in particular to a hydrogel, a preparation method and a freeze-dried support. Background technique [0002] Biological hydrogels have been widely used in tissue engineering. According to literature records, their main application areas include wound repair, tissue and organ regeneration, drug sustained release, etc. Existing sources of raw materials for hydrogels can be divided into natural materials and synthetic materials. Natural materials include collagen, chitosan, and cytoplasmic matrix. Synthetic materials include Pluronic and polyethylene glycol (PEG). [0003] The hydrogel formed by natural materials has poor mechanical properties and fast biodegradation rate, which limits its clinical application. At the same time, there are still some materials derived from animals, which have poor immunogenicity. Although synthetic materials have good prospects for improving mechanical ...
Claims
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IPC IPC(8): C08J3/075C08J3/28C08L89/00C08H1/00A61L27/22A61L27/52
CPCA61L27/227A61L27/52C08H1/00C08J3/075C08J3/28C08J2389/00
Inventor 杨自言
Owner JIANGSU TRAUTEC MEDICAL TECH CO LTD