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Method to eliminate periodic noise from data collected by chromatography system

A chromatographic system, a technique for collecting data, applied in the field of eliminating periodic noise from data collected with a chromatographic system, capable of solving problems such as reduced pump pulse sensitivity, limited sensitivity pump pulse pickup, etc.

Active Publication Date: 2019-11-08
WYATT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many ways to design instruments so that they are inherently less sensitive to pump pulses, an example of which is described below, but even after optimizing the pump and instrument, the sensitivity of the instrument is often still limited by the pump pulse pickup

Method used

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  • Method to eliminate periodic noise from data collected by chromatography system
  • Method to eliminate periodic noise from data collected by chromatography system
  • Method to eliminate periodic noise from data collected by chromatography system

Examples

Experimental program
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Embodiment Construction

[0018] Design instruments to inherently accommodate the effects of pump pulses

[0019] For certainty, an online viscometer may be considered to measure the change in viscosity of a liquid sample as the chromatographic peak passes the detector. Probably one of the simplest implementations is a single capillary design, examples of which are figure 1 shown. Pump 101 draws fluid from reservoir 102 and passes it through sensing capillary 103 . Differential transducer 104 measures the pressure across the capillary. The measured pressure is proportional to the flow rate and sample viscosity. If the solvent is first passed through the capillary and the baseline pressure P 0 , and subsequently inject the sample, the specific viscosity is simply

[0020] n sp (t)=P s (t) / P 0 -1 (1)

[0021] where P s (t) is the pressure of the sample. A key problem arising from such a flow system is that pump pulses generate a pressure signal that appears to be equivalent to a change in samp...

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PUM

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Abstract

A method to filter out pump pulses from data collected by a chromatography system is disclosed. Baseline data is collected as a pump delivers solvent to an analytical instrument, which may be the IP signal of a capillary bridge viscometer. A Fourier transform is applied to the data to generate the power spectrum of the baseline signal. Fundamental and harmonic frequencies are determined and a combfilter is constructed therefrom and applied to sample collected from all of the affected instruments. The comb filter may be correlated to the pump and flow rate and stored in data analysis softwareor database. Other systems using other pumps may also generate associated comb filters, and the resulting filters and the flow rates at which they were generated may be stored in a database accessibleto the data analysis software.

Description

[0001] Related patents and applications [0002] The following references relate to the background and application of the present invention and are incorporated herein by reference. [0003] Steven P. Trainoff, US Patent No. 7,213,439, issued May 8, 2007, "Automatic bridge balancing means and method for a capillary bridge viscometer." [0004] Steven P. Trainoff, US Patent No. 7,331,218, issued February 19, 2008, "Capillarybridge viscometer and method for measuring specific viscosity (capillary bridge viscometer and method for measuring specific viscosity)." [0005] Steven P. Trainoff, PCT Application No. PCT / US 16 / 41649, filed July 8, 2016, "Differential viscometer with solvent compressibility correction." Background technique [0006] Liquid chromatography systems have complex computer-controlled pumps that deliver solvent and sample through a column that separates the sample into its constituent components. The separated samples then flow through one or more analytical i...

Claims

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Application Information

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IPC IPC(8): G01N30/02B01D15/08G01N11/00G01N30/26G01N30/34G01N30/74
CPCG01N30/8617G01N30/8641G01N30/8658G01N30/62G01N2030/621G01N30/74G01N30/78
Inventor S·特拉诺夫
Owner WYATT TECH
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