Method and system for screening cancer biomolecular markers based on network topology parameters

Abstract

The invention discloses a method and system for screening cancer biomolecular markers based on network topology parameters. The method includes: acquiring human intergenic interaction network and gene chip expression data, and integrating the intergenic interaction based on the gene expression data. Network; construct the interaction network between genes in the disease state and the control state; calculate the network topology parameter difference gene between the disease state and the control state gene interaction network, and obtain the network topology parameter difference change network based on the network parameter difference gene; Mining the network modules of the topological parameter difference network; performing feature selection on the obtained difference network modules to obtain the genes that are distinguishable between normal and disease in each module; detecting the classification effect of the genes selected in each module on diseases, and screening according to the classification effect Differential network modules as biomolecular marker candidates. The present invention provides a new complex disease biomarker recognition method based on omics data, which is proved to have certain accuracy and effectiveness by experiments.

Description

technical field

[0001] The invention belongs to the technical field of biological information extraction, and in particular relates to a method and system for screening cancer biomolecular markers based on network topology parameters. Background technique

[0002] The statements in this section merely provide background information related to the present disclosure and do not necessarily constitute prior art.

[0003] Cancer (malignant tumor) is a large class of diseases that threaten human life and health, and its morbidity and mortality are increasing year by year worldwide. According to data, in 2018, 18.1 million new cancer cases and 9.6 million cancer deaths are expected to occur, of which China is expected to have over 4.05 million new cancer cases and over 2.61 million cancer deaths, and an average of 10,000 people are diagnosed with cancer every day , the situation is very serious.

[0004] Liver cancer (liver cancer), that is, malignant liver tumors, is the sixth ...

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