Millettia specisoa root extract having effect of strengthening sexual function and preparation method and application of millettia specisoa root extract

A Niu Dali and extract technology, which is applied to medical preparations containing active ingredients, organic active ingredients, sexual diseases, etc., can solve the problems of incomplete active ingredients, many impurities, and low concentrations, and achieve full dissolution and separation efficiency. High, easy-to-operate effects

Active Publication Date: 2019-11-15
YULIN NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the preparation process of Niu Dali extract is mainly traditional water extraction or alcohol extraction. For example, the invention patent with the patent publication number of CN106236825A discloses the application of Niu Dali and its extract in antidepressant. The extract is prepared by simple water reflux Extraction method, the obtained Niu Dali extract can be used to prepare antidepressant drugs or health care products; the invention patent with the patent publication number of CN103040924A discloses Niu Dali extract and its application in the preparation of osteoporosis drugs, using ethanol reflux extraction, The corresponding extract is obtained by organic solvent extraction, and the extract has a significant effect on improving osteoporosis; in addition, the invention patent with the patent publication number of CN105432898A discloses a compound tea of ​​Niu Dali extract and its preparation method. The preparation process of Niu Dali extract includes continuous Countercurrent ultrasonic extraction, enzymatic hydrolysis, ultrafiltration and other processes, the above extraction processes all have problems such as incomplete active ingredients, low concentration, low purity or more impurities

Method used

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  • Millettia specisoa root extract having effect of strengthening sexual function and preparation method and application of millettia specisoa root extract
  • Millettia specisoa root extract having effect of strengthening sexual function and preparation method and application of millettia specisoa root extract
  • Millettia specisoa root extract having effect of strengthening sexual function and preparation method and application of millettia specisoa root extract

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preparation example Construction

[0026] A method for preparing a bovine vigorous extract with the effect of enhancing sexual function, comprising the following preparation steps:

[0027] (1) Ultrasonic-assisted compound enzyme extraction: Grind and sieve Niu Dali root to obtain Niu Dali coarse powder, add water to the Niu Dali coarse powder and stir evenly, add compound enzyme for enzymatic hydrolysis, and place the mixture in an ultrasonic field for treatment , the enzymolysis solution is obtained after the compound enzyme is inactivated after the treatment is completed, and the filter residue A1 and the filtrate A2 are obtained by filtering after cooling.

[0028] Wherein, add 8~16 times of volumes of water to beef vigorous meal, the compound enzyme added comprises cellulase, xylanase and neutral protease, and described cellulase, xylanase and neutral protease The added amount is 0.4-0.8%, 0.2-0.6% and 0.6-1.0% of the mass of beef vigorous meal respectively, the pH value of the compound enzyme is 5.5-7.0, ...

Embodiment 1

[0040] (1) Ultrasonic-assisted compound enzyme extraction: Grind and sieve Niu Dali root to obtain Niu Dali coarse powder, add 12 times the volume of water to the Niu Dali coarse powder, stir well, add compound enzyme for enzymolysis, and place the mixture in ultrasonic Processing in the field, the compound enzyme that adds comprises cellulase, xylanase and neutral protease, and the addition amount of described cellulase, xylanase and neutral protease is successively 0.8 of the quality of beef hard meal. %, 0.4%, 1.0%, the pH value of the complex enzyme is 6.0, the enzymatic hydrolysis temperature is 50°C, the ultrasonic power is 350W, and the treatment time is 2h. Filtrate with a 0.8 μm filter membrane to obtain filter residue A1 and filtrate A2.

[0041] (2) Alcohol precipitation: Concentrate the filtrate A2 obtained in step (1) to 1 / 4 of the original volume, add ethanol with a concentration of 95% to the concentrated solution until the final concentration of ethanol is 80%,...

Embodiment 2

[0047] (1) Ultrasonic-assisted compound enzyme extraction: Grind and sieve Niu Dali root to obtain Niu Dali coarse powder, add 8 times the volume of water to Niu Dali coarse powder, stir evenly, add compound enzyme for enzymolysis, and place the mixture in ultrasonic Processing in the field, the compound enzyme added comprises cellulase, xylanase and neutral protease, and the addition amount of described cellulase, xylanase and neutral protease is successively 0.4 of the quality of cow's vigorous meal. %, 0.6%, 0.6%, the pH value of the compound enzyme is 6.5, the enzymatic hydrolysis temperature is 45°C, the ultrasonic power is 200W, and the treatment time is 1h. Filtrate with a 0.8 μm filter membrane to obtain filter residue A1 and filtrate A2.

[0048] (2) Alcohol precipitation: Concentrate the filtrate A2 obtained in step (1) to 1 / 4 of the original volume, add ethanol with a concentration of 95% to the concentrated solution until the final concentration of ethanol is 80%, ...

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Abstract

The invention relates to the fields of a traditional Chinese medicine extraction technique and application, and aims to disclose an extract having the effect of strengthening sexual function. The extract is a mixture prepared by mixing the following raw materials in parts by weight of 3-5 parts of millettia specisoa root polysaccharide, 1-3 parts of millettia specisoa root total flavonoids, and 1-3 parts of millettia specisoa root alkaloid. The invention discloses a preparation method of the millettia specisoa root extract having effect of strengthening sexual function. According to the millettia specisoa root extract prepared by the method, effective components of millettia specisoa roots can be extracted to the maximum extent. The invention further provides an application of the extract.

Description

technical field [0001] The present invention relates to the field of traditional Chinese medicine extraction technology and application, more specifically, especially to a bovine vigorous extract which can enhance sexual function; the present invention also relates to the preparation method and application of the extract. Background technique [0002] Sexual dysfunction is caused by many reasons such as heredity, health status, hormone level, age, disease (including chronic diseases, neuropsychiatric disorders, endocrine diseases, genital organ lesions), drugs, long-term heavy drinking or drug abuse, will also Sexual dysfunction occurs. Male sexual dysfunction mainly includes sexual desire disorder, penile erection disorder and sexual intercourse disorder. At present, there are many kinds of sexual function enhancing drugs on the market. European and American countries mainly use synthetic drugs or hormones, which have strong effects and are prone to drug resistance after l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/486A61P15/08A61P39/00A61K125/00A61K31/715
CPCA61K36/486A61K31/715A61P15/08A61P39/00A61K2236/19A61K2236/331A61K2236/51A61K2236/333A61K2236/39A61K2236/55A61K2300/00Y02A50/30
Inventor 蒋德旗臧青民
Owner YULIN NORMAL UNIVERSITY
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