Insulin analog complex with reduced affinity for insulin receptor and use thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HANMI PHARMA
- Publication Date
- 2019-12-03
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Abstract
Description
technical field
[0001] The present invention relates to conjugates of insulin analogues and uses thereof. Background technique
[0002] It is known that proteins in the body are removed through various routes, including decomposition by proteases in the blood, excretion through the kidneys, removal through receptors, and the like. In this regard, various attempts have been made to improve the therapeutic effect of proteins by avoiding protein clearance mechanisms to increase the half-life of physiological proteins.
[0003] In general, insulin is a hormone secreted by the pancreas of the human body, which regulates blood sugar levels and has the effect of maintaining normal blood sugar levels while carrying excess glucose in the blood to cells to provide energy for the cells. However, in diabetics, insulin does not work properly due to insulin deficiency, resistance to insulin and loss of beta cell function. As a result, diabetic patients cannot utilize blood sugar as an e...