Composition prepared from radix astragali, radix puerariae and herba erigerontis, and application of composition
A technology of Erigeron breviscapus and its composition, which is applied in the field of compositions containing astragalus, kudzu root and Erigeron breviscapus and their uses, and can solve the problems of different effects, complex natural medicinal ingredients, and no compatibility to effectively treat macular edema.
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[0053] In a specific embodiment, the preparation method of the composition comprising Radix Astragalus, Pueraria Radix and Erigeron breviscapus of the present application comprises the following steps:
[0054] a. Take the raw materials of the following weight ratio:
[0055] 10-40 parts of astragalus, 10-30 parts of kudzu root, 10-30 parts of escutellaria;
[0056] b. Pueraria puerariae is crushed into coarse powder, extracted with 60-95% ethanol, filtered, combined filtrate, recovered ethanol, concentrated, passed through a macroporous adsorption resin column, washed with water, discarded the water eluate, and then used 10-95% % ethanol for elution, collect the ethanol eluate, reclaim ethanol, concentrate into a thick paste, dry under reduced pressure, pulverize into fine powder, and obtain the kudzu root extract;
[0057] c. Astragalus is crushed into coarse powder, heated and refluxed with 60-95% ethanol to extract, filtered, combined filtrate, recovered ethanol, concentr...
Embodiment 1
[0075] Example 1: Preparation of a composition comprising astragalus, kudzu root and scutellaria
[0076] Weigh 30kg of Pueraria lobata, 20kg of Erigeron breviscapine, and 20kg of Astragalus membranaceus, pulverize Pueraria root into coarse powder, heat and reflux with 60% ethanol to extract twice, each time for 1 hour, filter, combine the filtrates, recover ethanol, concentrate properly, and add to the treated On a good macroporous adsorption resin column, elute with water, discard the water eluent, continue to elute with 70% ethanol, collect the ethanol eluate, concentrate under reduced pressure into a thick paste, dry under reduced pressure, and pulverize into fine powder. kudzu root extract;
[0077] Astragalus is crushed into coarse powder, heated and refluxed with 90% ethanol to extract three times, each time for 1 hour, filtered, combined filtrate, recovered ethanol, concentrated properly, added sodium hydroxide until the alkali content is 5%, added n-butanol for dynami...
Embodiment 2
[0080] Embodiment 2: The therapeutic effect of the composition of the present application on diabetic macular edema
[0081] 2.1 Experimental program design
[0082] Test population
[0083] Select patients who meet the diagnostic criteria of diabetic retinopathy (qi-yin deficiency, blood stasis syndrome) syndrome; the subjects were informed and voluntarily signed the informed consent. The subjects were divided into four groups A, B, C and D.
[0084] Dosing regimen
[0085] The dosage of each group is as follows, and the course of treatment is 24 weeks:
[0086] Group A is a high-dose group, each administration of 4 capsules prepared according to the method described in Example 1, three times a day, with a daily dosage of 66 mg / kg body weight / day;
[0087] Group B is a middle-dose group, each administration of 2 capsules prepared according to the method described in Example 1, three times a day, with a daily dosage of 33 mg / kg body weight / day;
[0088] Group C is a l...
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