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Composition prepared from radix astragali, radix puerariae and herba erigerontis, and application of composition

A technology of Erigeron breviscapus and its composition, which is applied in the field of compositions containing astragalus, kudzu root and Erigeron breviscapus and their uses, and can solve the problems of different effects, complex natural medicinal ingredients, and no compatibility to effectively treat macular edema.

Inactive Publication Date: 2019-12-06
CHONGQING TAIJI INDAL GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Due to its high safety, traditional Chinese medicine is gradually used in the treatment of various ophthalmic diseases. However, due to the complex composition of natural medicines, the effects of drug compatibility may be different. At present, there is no effective treatment of macular edema, especially macular edema, using traditional Chinese medicine as raw materials. Related reports on diabetic macular edema

Method used

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  • Composition prepared from radix astragali, radix puerariae and herba erigerontis, and application of composition
  • Composition prepared from radix astragali, radix puerariae and herba erigerontis, and application of composition
  • Composition prepared from radix astragali, radix puerariae and herba erigerontis, and application of composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0053] In a specific embodiment, the preparation method of the composition comprising Radix Astragalus, Pueraria Radix and Erigeron breviscapus of the present application comprises the following steps:

[0054] a. Take the raw materials of the following weight ratio:

[0055] 10-40 parts of astragalus, 10-30 parts of kudzu root, 10-30 parts of escutellaria;

[0056] b. Pueraria puerariae is crushed into coarse powder, extracted with 60-95% ethanol, filtered, combined filtrate, recovered ethanol, concentrated, passed through a macroporous adsorption resin column, washed with water, discarded the water eluate, and then used 10-95% % ethanol for elution, collect the ethanol eluate, reclaim ethanol, concentrate into a thick paste, dry under reduced pressure, pulverize into fine powder, and obtain the kudzu root extract;

[0057] c. Astragalus is crushed into coarse powder, heated and refluxed with 60-95% ethanol to extract, filtered, combined filtrate, recovered ethanol, concentr...

Embodiment 1

[0075] Example 1: Preparation of a composition comprising astragalus, kudzu root and scutellaria

[0076] Weigh 30kg of Pueraria lobata, 20kg of Erigeron breviscapine, and 20kg of Astragalus membranaceus, pulverize Pueraria root into coarse powder, heat and reflux with 60% ethanol to extract twice, each time for 1 hour, filter, combine the filtrates, recover ethanol, concentrate properly, and add to the treated On a good macroporous adsorption resin column, elute with water, discard the water eluent, continue to elute with 70% ethanol, collect the ethanol eluate, concentrate under reduced pressure into a thick paste, dry under reduced pressure, and pulverize into fine powder. kudzu root extract;

[0077] Astragalus is crushed into coarse powder, heated and refluxed with 90% ethanol to extract three times, each time for 1 hour, filtered, combined filtrate, recovered ethanol, concentrated properly, added sodium hydroxide until the alkali content is 5%, added n-butanol for dynami...

Embodiment 2

[0080] Embodiment 2: The therapeutic effect of the composition of the present application on diabetic macular edema

[0081] 2.1 Experimental program design

[0082] Test population

[0083] Select patients who meet the diagnostic criteria of diabetic retinopathy (qi-yin deficiency, blood stasis syndrome) syndrome; the subjects were informed and voluntarily signed the informed consent. The subjects were divided into four groups A, B, C and D.

[0084] Dosing regimen

[0085] The dosage of each group is as follows, and the course of treatment is 24 weeks:

[0086] Group A is a high-dose group, each administration of 4 capsules prepared according to the method described in Example 1, three times a day, with a daily dosage of 66 mg / kg body weight / day;

[0087] Group B is a middle-dose group, each administration of 2 capsules prepared according to the method described in Example 1, three times a day, with a daily dosage of 33 mg / kg body weight / day;

[0088] Group C is a l...

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Abstract

The invention provides application of a composition prepared from radix astragali, radix puerariae and herba erigerontis to preparation of drugs for treating or preventing macular oedema of individuals.

Description

technical field [0001] The present application relates to a composition comprising Astragalus, Pueraria Radix and Erigeron breviscapus and uses thereof, specifically, the present application relates to the use of a composition comprising Astragalus membranaceus, Pueraria Radix and Erigeron breviscapus in treating diseases of the macular region. Background technique [0002] The macula is a shallow funnel-shaped depression with a diameter of about 2 mm located at the posterior pole of the retina, and there is a small depression in the center of the retina called the fovea. The macular area is the most important part of the retina to produce visual signals. Any lesion in the macular area will affect vision and even lead to serious consequences of blindness. With the development and progress of medicine, the harm of traditional blinding eye diseases such as "cataract" has been greatly reduced, while the serious impact of macular disease on vision is particularly prominent. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61P27/02A61P3/10
CPCA61K36/28A61K36/481A61K36/488A61P3/10A61P27/02A61K2300/00A61K9/00A61K9/48A61P27/00
Inventor 白礼西段俊国孙克宏秦少容郑飞鸣卿玉玲黄静张颖刘世琪王磊原欢欢冉亚东
Owner CHONGQING TAIJI INDAL GROUP
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