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Freeze-drying processing method of figwort root

A processing method, vacuum freeze-drying technology, which is applied in the direction of drying solid materials, drying solid materials without heating, drying, etc., can solve the problems of unsafety, limited use range, and inability to effectively retain the active ingredient harpaside of Scrophulariaceae , to achieve the effect of avoiding damage and ensuring quality

Active Publication Date: 2019-12-06
YUNNAN YIKANG CHINESE HERBAL PIECES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process is actually a post-processing process of Scrophulariaceae. Although the addition of microcrystalline cellulose and Tween 80 can make fresh Scrophulariaceae easier to powder after freeze-drying, there are auxiliary materials added in it, and Tween 80 is relatively safe, but For some people with allergic constitution, there are still unsafe factors. Therefore, the scope of use of fresh Scrophulariaceae superfine powder processed by this process is limited.
[0009] It can be seen from the above that the current heat-drying treatment method cannot effectively retain the active ingredients harpagoside and harpagoside in Scrophulariae scrophulariae, but freeze-drying can avoid the oxidation and hydrolysis of the active ingredients and achieve the maximum preservation effect

Method used

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  • Freeze-drying processing method of figwort root
  • Freeze-drying processing method of figwort root

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Material selection: Fresh Scrophulariaceae excavated when the stems and leaves wither in winter, remove the rhizomes, young shoots, fibrous roots and sediment, clean, drain, and cut into thin slices with a thickness of 1-3mm while fresh.

[0034] (2) Pre-freezing: put clean Scrophulariaceae into a vacuum freeze dryer for pre-freezing at -10°C for 3 hours to obtain pre-frozen Scrophulariaceae.

[0035] (3) Step-by-step freezing: The pre-frozen Scrophulariaceae is subjected to step-by-step freezing in three stages: the first stage, from -15°C to -25°C, cooling at a rate of 0.7°C / min for 3 hours; the second stage, From -25°C to -35°C, cool down at a rate of 0.7°C / min for 3 hours; in the third stage, from -35°C to -40°C, cool down at a rate of 1.5°C / min for 1.5h.

[0036] (4) Heating and drying: the vacuum degree is 60±5Pa, and it is carried out in three stages: the first stage, from -45°C to -20°C, the temperature is raised at a rate of 0.7°C / min, and lasts for 4h; the...

Embodiment 2

[0039] (1) Material selection: Fresh Scrophulariaceae excavated when the stems and leaves wither in winter, remove the rhizomes, young shoots, fibrous roots and sediment, clean, drain, and cut into thin slices with a thickness of 1-3mm while fresh.

[0040] (2) Pre-freezing: put clean Scrophulariaceae into a vacuum freeze dryer for pre-freezing at -5°C for 2 hours to obtain pre-frozen Scrophulariaceae.

[0041] (3) Step-by-step freezing: The pre-frozen Scrophulariaceae is subjected to step-by-step freezing in three stages: the first stage, from -15°C to -25°C, cooling at a rate of 0.5°C / min for 2 hours; the second stage, From -25°C to -35°C, cool down at a rate of 0.5°C / min for 2 hours; in the third stage, from -35°C to -40°C, cool down at a rate of 1°C / min for 1 hour.

[0042] (4) Heating and drying: the vacuum degree is 60±5Pa, and it is carried out in three stages: the first stage, from -45°C to -20°C, the temperature is raised at a rate of 0.5°C / min for 3 hours; the second...

Embodiment 3

[0045] (1) Material selection: Fresh Scrophulariaceae excavated when the stems and leaves wither in winter, remove the rhizomes, young shoots, fibrous roots and sediment, clean, drain, and cut into thin slices with a thickness of 1-3mm while fresh.

[0046] (2) Pre-freezing: put clean Scrophulariaceae into a vacuum freeze dryer for pre-freezing at -15°C for 4 hours to obtain pre-frozen Scrophulariaceae.

[0047] (3) Step-by-step freezing: The pre-frozen Scrophulariaceae is subjected to step-by-step freezing in three stages: the first stage, from -15°C to -25°C, cooling at a rate of 1°C / min for 4 hours; the second stage, From -25°C to -35°C, cool down at a rate of 1°C / min for 4 hours; in the third stage, from -35°C to -40°C, cool down at a rate of 2°C / min for 2 hours.

[0048] (4) Heating and drying: the vacuum degree is 60±5Pa, and it is carried out in three stages: the first stage, from -45°C to -20°C, the temperature is raised at a rate of 1°C / min, and lasts for 6h; the seco...

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Abstract

The invention discloses a freeze-drying method of figwort root. After the fresh figwort root are selected to be sliced, freeze-drying is conducted, factors such as the temperature, the rate of temperature change, and the duration are controlled during pre-freezing, step-by-step freezing, and heating drying so as to prevent effective ingredients of figwort root harpagide and harpagoside from beingdestructed during processing, and quality of a figwort root medical material is ensured. (That is, the figwort root index component content stipulated in the 2015 edition of Chinese pharmacopoeia), compared with a general drying method, the figwort root medical material produced by the freeze-drying method is stable and controllable, and is unaffected by external factors, and the quality of a finished medical material product is high.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicinal materials, and in particular relates to a drying method in the processing of Scrophulariaceae, in particular to a method for drying Scrophulariaceae by means of freeze-drying. Background technique [0002] Zhongsheng Pill is one of the exclusive varieties of Guangdong Zhongsheng Pharmaceutical Co., Ltd., and implements the standard Zhongsheng Pill (WS 3 -B-2880-98), the prescription consists of Banlangen, Bupleurum, Radix Paeoniae Rubra, Angelica, Polygonum cuspidatum, Scutellaria baicalensis, Dandelion, Scrophulariae, Viola, Fangfeng, Angelica dahurica, Gangmei, Dannanxing, Prunella vulgaris, Trichosanthes, and artificial bezoar , Saponaria thorn and other seventeen medicinal materials, the functions and indications are heat-clearing and detoxifying, promoting blood circulation and cooling blood, reducing inflammation and relieving pain. Mainly used for the treatment of upper respira...

Claims

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Application Information

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IPC IPC(8): A61K36/808F26B5/06
CPCA61K36/808F26B5/06A61K2236/13A61K2236/17
Inventor 张新轩蓝天秀祁健斌
Owner YUNNAN YIKANG CHINESE HERBAL PIECES CO LTD
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