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Extraction process of berberine

An extraction process, berberine technology, applied in the direction of organic chemistry and so on

Inactive Publication Date: 2019-12-06
NANJING ZELANG AGRI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report that this method is used to extract berberine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Cut Coptis chinensis into 1~2cm small pieces and place them in a homogenizer, add extraction solvent 70% ethanol, mix and homogenate in the homogenizer, the power of the homogenizer is 160W, the homogenization speed is 8000r / min, after homogenization The material is placed in an ultrasonic device, extracted for 2 hours, and filtered with a microfiltration membrane, the microfiltration membrane is Al 2 o 3 , 0.2 μm, concentrated under reduced pressure to 1 / 4 of the original volume, dissolved the above extract with ethanol solution, added activated carbon to reflux for decolorization, concentrated the decolorized solution and extracted it with ether, concentrated and crystallized the extract to obtain berberine.

Embodiment 2

[0015] Cut Coptis chinensis into 1~2cm small pieces and place them in a homogenizer, add extraction solvent 80% ethanol, mix and homogenate in the homogenizer, the power of the homogenizer is 160W, the homogenization speed is 12000r / min, after homogenization The material is placed in an ultrasonic device, extracted for 2 hours, and filtered with a microfiltration membrane, the microfiltration membrane is Al 2 o 3 , 0.2 μm, concentrated under reduced pressure to 1 / 6 of the original volume, the above extract was dissolved in ethanol solution, added activated carbon to reflux for decolorization, the decolorized solution was concentrated and then extracted with ether, the extract was concentrated and crystallized to obtain berberine.

Embodiment 3

[0017] Cut Coptis chinensis into 1~2cm pieces and put them in the homogenizer, add the extraction solvent 75% ethanol, mix and homogenate in the homogenizer, the power of the homogenizer is 160W, the speed of homogenization is 10000r / min, after homogenization The material is placed in an ultrasonic device, extracted for 2 hours, and filtered with a microfiltration membrane, the microfiltration membrane is Al 2 o 3 , 0.2 μm, concentrated under reduced pressure to 1 / 5 of the original volume, dissolved the above extract with ethanol solution, added activated carbon to reflux for decolorization, concentrated the decolorized solution and extracted it with ether, concentrated and crystallized the extract to obtain berberine.

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PUM

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Abstract

The invention relates to an extraction process of berberine, particularly to a process for extracting berberine by combining a homogenization method and ultrasonic waves. The process is characterizedby comprising the following steps: a, cutting Coptis chinensis into small sections with length of 1-2 cm, putting the small sections into a homogenizer, adding an extraction solvent, and carrying outmixing and homogenizing in the homogenizer; b, putting a homogenized material into an ultrasonic device, and carrying out extracting for 2 h; c, carrying out filtering by using a micro-filtration membrane, and then performing vacuum concentration until the volume of the obtained extract is 1 / 4-1 / 6 of the original volume of the material; and d, dissolving the extract with an ethanol solution, adding activated carbon for reflux decolorization, concentrating a decolorized solution, then carrying out extracting with diethyl ether, and concentrating and crystallizing the obtained liquid extract toobtain berberine. The process has the advantages of simple process flow, rapidness and high efficiency; meanwhile, only a small amount of the organic solvent is used in the whole process, so cost canbe reduced; and the extraction process has good application prospects.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, and relates to an extraction process of berberine, in particular to a method for extracting berberine by combining a homogenization method and ultrasonic waves. Background technique [0002] Homogenization extraction refers to an extraction method in which the tissue is homogenized or refined by adding an extraction solvent to extract the active ingredients in the tissue. The homogenization method is used to extract the active ingredients of plants. The material can be directly placed in the homogenizer, mixed and homogenized with the extraction solvent in the homogenization device, and the material is torn and crushed by mechanical and hydraulic shearing, so that the material is broken. It is carried out simultaneously with the extraction of active ingredients to achieve the purpose of rapid and intensive extraction of plant active ingredients. The method has the characteristics of com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D455/03
CPCC07D455/03
Inventor 杨成东
Owner NANJING ZELANG AGRI DEV