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Calcium sulfate-containing polyetheretherketone particulate bone filling material and preparation method thereof

A technology of polyether ether ketone and filling materials, which is applied in medical science, tissue regeneration, prostheses, etc., and can solve problems such as the mismatch between the degradation rate of polymer synthetic materials and the bone formation rate, difficulty in shaping, and inflammatory reactions

Inactive Publication Date: 2019-12-13
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although autologous bone is an ideal material for bone defect repair, the process of bone extraction increases the trauma and pain of patients, and the source of bone supply is limited, making it difficult to shape and meet the requirements of large bone transplantation; allograft bone has immune rejection , may spread the disease and cause postoperative complications; metal prostheses are prone to loosening, breaking, poor tissue compatibility, and inflammatory reactions; polymer synthetic materials have a mismatch between the degradation rate and the osteogenesis rate, and the degradation by-products change the surrounding microenvironment and thus Problems such as affecting bone repair have limited clinical application to varying degrees.

Method used

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  • Calcium sulfate-containing polyetheretherketone particulate bone filling material and preparation method thereof
  • Calcium sulfate-containing polyetheretherketone particulate bone filling material and preparation method thereof
  • Calcium sulfate-containing polyetheretherketone particulate bone filling material and preparation method thereof

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preparation example Construction

[0025] The invention provides a preparation method of calcium sulfate-containing polyether ether ketone particulate bone filling material, comprising the following steps:

[0026] PEEK powder, concentrated sulfuric acid and CaSO 4 Stand still after mixing to obtain a mixed solution;

[0027] The mixed liquid was prepared by airflow method and then settled in ethanol-CaSO 4 saturated solution, and then in ethanol-CaSO 4 Soak in saturated liquid and sieve to obtain CaSO with a particle size of 500-600 μm 4 - PEEK particles;

[0028] CaSO with a particle size of 500-600 μm 4 -PEEK particles and CaSO 4 The saturated liquid is hydrothermally treated and vacuum-dried to obtain calcium sulfate-containing polyether ether ketone particulate bone filling material with a particle diameter of 400-500 μm.

[0029] Method provided by the invention adopts CaSO 4 By blending polyetheretherketone powder, the obtained blended material has high hydrophilicity, which is beneficial to cell ...

Embodiment 1

[0046] Weigh 1.8g of PEEK powder, add it to 30mL of concentrated sulfuric acid, place it in a water bath at 25°C, and stir it mechanically for one hour. After the PEEK powder is completely dissolved, add different masses of CaSO 4 , CaSO 4 The mass accounted for PEEK powder and CaSO 4 10% of the total mass; mechanically stirred again for one hour, and the CaSO 4 After the dispersion is uniform, let it stand still, add the above mixed liquid into a 50mL syringe, the Teflon needle diameters are 27G, 26G and 25G, and equip with 1000mL of 30% ethanol / CaSO 4 The saturated liquid is used as the sedimentation liquid, in an ice bath, the height of the needle from the liquid surface of the sedimentation liquid is 14cm, and the CaSO is prepared by the airflow method 4 / PEEK particles, the air flow rate is 6~7L / min. Get CaSO 4 - After PEEK microparticles, CaSO 4 Soak in the saturated solution for 24 hours, change the soaking solution every 8 hours, and filter through a sieve to obta...

Embodiment 2

[0050] Different from Example 1, CaSO 4 The mass accounted for PEEK powder and CaSO 4 20% of the total mass.

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Abstract

The present invention provides a calcium sulfate-containing polyetheretherketone particulate bone filling material and a preparation method thereof. The method comprises the following steps: after mixing polyetheretherketone powder, concentrated sulfuric acid and CaSO4, putting still is conducted to obtain a mixed solution; after preparing the mixed solution into micro-particles by using an air flow method, settling the micro-particles in an ethanol-CaSO4 saturated solution, then soaking the micro-particles in the ethanol-CaSO4 saturated solution, and sieving the micro-particles; and carryingout a hydrothermal treatment on the obtained CaSO4-PEEK micro-particles with a particle size of 500-600 [mu]m and the CaSO4 saturated solution and carrying out vacuum drying to obtain the calcium sulfate-containing polyetheretherketone particulate bone filling material with a particle size of 400-500 [mu]m. The method uses the CaSO4 to conduct co-blending of the polyetheretherketone powder, and the obtained co-blended material has high hydrophilicity, is beneficial to cell proliferation and adhesion, promotes cell differentiation, improves biomineralization capability, enhances osteoinductiveproperty and biological activity, promotes full fusion with tissues, can also be used as a microcarrier for carrying growth factors, etc.

Description

technical field [0001] The invention belongs to the technical field of bone repair materials, and in particular relates to a calcium sulfate-containing polyether ether ketone particulate bone filling material and a preparation method thereof. Background technique [0002] In the field of orthopedics, bone defects due to severe trauma, bone tumors, osteomyelitis and other reasons are very common, especially large and irregular bone defects. Which material and method to use for bone graft surgery is a hot spot in current research. Currently, bone repair materials commonly used clinically include autologous bone, allogeneic bone, metal prosthesis, and polymer synthetic materials. Although autologous bone is an ideal material for bone defect repair, the process of bone extraction increases the trauma and pain of patients, and the source of bone supply is limited, making it difficult to shape and meet the requirements of large bone transplantation; allograft bone has immune reje...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/50A61L27/56
CPCA61L27/446A61L27/50A61L27/56A61L2430/02C08L61/16
Inventor 章培标纪庆明焦自学王宗良孙烁王鹏
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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