Plant extract nanoparticle, and preparation method and application thereof

A technology of plant extracts and nanoparticles, applied in nanotechnology, nanotechnology, nanomedicine, etc., to achieve the effect of solving poor solubility, high stability, and narrow particle size distribution range

Inactive Publication Date: 2019-12-13
北京天然纳美健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] At present, there is no report about the nanoparticles of latani extract and totolol. In order to improve the dissolution and absorpt

Method used

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  • Plant extract nanoparticle, and preparation method and application thereof
  • Plant extract nanoparticle, and preparation method and application thereof
  • Plant extract nanoparticle, and preparation method and application thereof

Examples

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Embodiment 1

[0043] The present embodiment provides a kind of latani extract nanoparticle, and it is stabilizer with egg yolk lecithin (EPC), and the mass ratio of latani extract and EPC is 1:1, and the latani extract in the nanoparticle preparation The concentration is 2mg / mL, and the specific preparation method is as follows:

[0044] Dissolve 10mg of Latani extract and 10mg of egg yolk lecithin (EPC) in 0.5mL of absolute ethanol, drop them into 5mL of pure water under 25°C, 24KHZ and 250W ultrasonic conditions, and remove the ethanol by rotary evaporation at 45°C to obtain .

Embodiment 2

[0046] The present embodiment provides a kind of latani extract nanoparticle, and it is stabilizer with egg yolk lecithin (EPC), and the mass ratio of latani extract and EPC is 2:1, and the latani extract in the nanoparticle preparation The concentration is 2mg / mL, and the specific preparation method is as follows:

[0047] Dissolve 10mg of Latani extract and 5mg of EPC in 0.5mL of absolute ethanol, drop them into 5mL of pure water under 25°C, 24KHZ and 250W ultrasonic conditions, and remove the ethanol by rotary evaporation at 45°C.

Embodiment 3

[0049] The present embodiment provides a kind of latani extract nanoparticle, and it is stabilizer with egg yolk lecithin (EPC), and the mass ratio of latani extract and EPC is 5:1, and the latani extract in the nanoparticle preparation The concentration is 2mg / mL, and the specific preparation method is as follows:

[0050] Dissolve 10mg of Latani extract and 2mg of egg yolk lecithin EPC in 0.5mL of absolute ethanol, drop them into 2mL of pure water at 25°C, 24KHZ and 250W ultrasonic conditions, and remove the ethanol by rotary evaporation at 45°C.

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Abstract

The invention relates to the technical field of plant extract preparations, and concretely relates to a plant extract nanoparticle, and a preparation method and an application thereof. The plant extract nanoparticle is a Krameria triandra extract nanoparticle or a totarol nanoparticle concretely, and is prepared from a plant extract, a stabilizer and a solvent. The plant extract nanoparticle solves the problem of poor solubility of the Krameria triandra extract and totarol and the problem of clinical and practical application difficulties caused by the poor solubility, has the advantages of good particle size uniformity, narrow particle size distribution range, non-agglomeration, high stability, freeness of organic solvents, small dosage of a surfactant, and high safety, and is suitable for being used alone or compounded with other active ingredients.

Description

technical field [0001] The invention relates to the technical field of plant extract preparations, in particular to a plant extract nanoparticle and its preparation method and application. Background technique [0002] With the continuous development of plant extract preparations, a large number of plant extracts and plant active ingredients have been developed and utilized. However, many plant active ingredients, such as silymarin, puerarin, breviscapine, paclitaxel, and artemisinin, have poor solubility, resulting in low bioavailability, which greatly limits the application of plant active ingredients. In order to solve the problem of low bioavailability of insoluble plant extracts, a variety of methods to increase solubility and speed up dissolution rate have been developed, such as solubilization, cyclodextrin inclusion technology, liposome, micronization, emulsion, etc. However, the above methods all have certain limitations, for example: the co-solvent has toxic and s...

Claims

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Application Information

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IPC IPC(8): B01D9/02A61K36/69A61K31/05A61K9/14A61K47/10A61K47/34A61K8/9789A61K8/34A61K8/55A61K8/86A61Q19/00B82Y5/00
CPCA61K8/347A61K8/553A61K8/86A61K9/145A61K9/146A61K31/05A61K36/69A61K2800/413A61Q19/00A61K8/9789B01D9/0081B82Y5/00A61K2300/00
Inventor 姚淑芬张文霞
Owner 北京天然纳美健康科技有限公司
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