Cannabidiol composition and application thereof
A cannabidiol and composition technology, applied in the field of cannabidiol-containing compositions, can solve problems such as potential safety hazards, dangers, etc., and achieve the effects of high stability, consistent pharmacokinetic behavior, and reduction of unpredictable risks
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0069] Example 1: Preparation of self-made poloxamer P-HY and determination of performance parameters
[0070] 1. The synthetic route of poloxamer (P-HY):
[0071]
[0072] (1) Condensate propylene oxide onto 1,2-propanediol to obtain a polyoxypropylene chimeric segment; wherein basic 1,2-propanediol is used as an inducer, and the molar ratio of each substance is propylene oxide: 1,2- Propylene glycol: KOH / NaOH=(220-320):1:(2-0.5), the reaction temperature is 90-120°C, the reaction end point (time) varies with different reaction conditions, and the reference standard is the end of the reflux state.
[0073] (2) Under the catalysis of potassium hydroxide (or sodium hydroxide) and EDTA, the ethylene oxide is condensed to the two ends of the polyoxypropylene chimeric segment obtained in step (1), and the molar ratio of the control starting material is ethylene oxide: Polyoxypropylene: potassium hydroxide (or sodium hydroxide): EDTA = (450-650): 1: (0.5-1): (0.05-0.1), the rea...
Embodiment 2
[0107] Embodiment 2: Preparation and performance measurement of cannabidiol composition
[0108] 1. Preparation process of cannabidiol composition
[0109] The cannabidiol composition described in this application can be prepared by the following process:
[0110] a) Physical grinding: Weigh the components of the prescription amount, place them in a suitable size mortar or a special machine for grinding, fully grind until the components described in the prescription are mixed evenly, and then mix the uniformly mixed materials Pulverize by means of physical or jet milling or passing through pharmacopoeia sieve;
[0111] b) Heating and melting: put each component of the prescription amount in a container of suitable size, heat to above 65°C, so that each component of the prescription is in a molten state, and then fully stir evenly at this temperature, and then Cool to room temperature, adopt the method described in a) to pulverize the homogeneous mixture;
[0112] c) Spray d...
Embodiment 3
[0153] Example 3: Biological Activity Evaluation of Cannabidiol Compositions
[0154] According to the method disclosed by GW PHARMA LTD in patent application GB2380129A and Russell Hobart Stebbins in patent application US20160143972A1, two samples for comparative research were prepared to evaluate the technical effect of the cannabidiol composition described in this application, mainly Including stability in gastric juice, bioavailability, plasma protein binding rate and so on.
[0155] Sample to be tested:
[0156] 1) Select the following nine groups of optimized formulas in Example 2 to prepare the composition according to the method described in a) in 1 and carry out subsequent experiments:
[0157] a. Prescription 1: Poloxamer P-HY:CBD:citric acid=100:1:0.01;
[0158] b. Prescription 2: Poloxamer P-HY:CBD:citric acid=50:1:0.01;
[0159] c. Prescription 3: Poloxamer P-HY:CBD:citric acid=100:1:0.02;
[0160] d Prescription 4: Poloxamer P-HY:CBD:citric acid=100:1:0.1;
...
PUM
| Property | Measurement | Unit |
|---|---|---|
| Particle size | aaaaa | aaaaa |
| Molecular weight | aaaaa | aaaaa |
| Molecular weight | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to view more - R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap