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Synthesis method and application of sulfonamide dimethylpyrimidine molecularly imprinted polymer

A technology of sulfamethazine and dimethylpyrimidine is applied in the field of synthesis of sulfonamide dimethylpyrimidine molecularly imprinted polymers, and can solve the problems of complex preparation process, many preparation process variables, general specificity and the like of surface imprinting technology , to achieve the effect of good identification and adsorption capacity, optimized solvent usage ratio, and excellent specific adsorption capacity

Active Publication Date: 2019-12-20
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, methacrylic acid and dimethacrylate alcohol diester are mostly used as functional monomers and cross-linking agents of sulfonamide antibiotics, but the specificity of this scheme is general when the bulk polymerization method is used [SHI Xizhi, MENG Yuan, LIU Jinghua, Journal of Chromatography B, 2011, 879], supplemented by surface imprinting polymerization technology to improve the specificity of molecularly imprinted polymers of sulfonamide drugs, while the preparation process of surface imprinting technology is complicated, the preparation process has many variables, and it is not easy to popularize

Method used

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  • Synthesis method and application of sulfonamide dimethylpyrimidine molecularly imprinted polymer
  • Synthesis method and application of sulfonamide dimethylpyrimidine molecularly imprinted polymer
  • Synthesis method and application of sulfonamide dimethylpyrimidine molecularly imprinted polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Study on the Specificity of Sulphonamide Molecularly Imprinted Polymers

[0050] 1. Preparation method:

[0051] (1) Preparation of MIP

[0052]According to template molecule: functional monomer: crosslinking agent: initiator, the addition ratio is 1mmol: 4mmol: 20mmol: 120mg to weigh each substance, that is, the amount of each substance is specifically: template molecule 0.27g sulfamethazine, 0.17g formazan Acrylic acid and 0.19g of diallylamine were dissolved in 4mL of methanol solvent, and pre-polymerized for 30min. After pre-polymerization, add 4mL cross-linking agent DVB and 120mg azobisisobutyronitrile initiator, sonicate for 10min, deoxygenate with nitrogen for 10min, seal and polymerize in a constant temperature water bath at 60°C for 12h to obtain a white solid.

[0053] After cooling the above reaction solution to room temperature, centrifuge, take the white precipitate, dry it, extract it with a mixed solvent of methanol and acetic acid with a vol...

Embodiment 2

[0060] Example 2 Optimization of functional monomer ratio

[0061] Based on the preparation and analysis method of MIP described in Example 1, under the same other conditions, a series of molecularly imprinted polymers were produced by changing the types of functional monomers, and the appropriate functional monomer types were screened on the basis of imprinting factors. The results showed that, Mixed functional monomers utilizing methacrylic acid and diallylamine are optimal.

[0062] Based on the preparation and analysis method of MIP described in Example 1, under the same other conditions, the ratio of the mixed functional monomer methacrylic acid and diallylamine was changed, wherein the designed molar ratio of the two was 4:0 in sequence , 3:1, 1:1, 1:3 and 0:4, the imprinting factors of MIP with different functional monomer ratios are shown in Table 1:

[0063] Table 1 Comparison table of specificity of MIP with different functional monomer ratios

[0064]

[0065] ...

Embodiment 3

[0067] Example 3 Cross-linking agent optimization

[0068] Based on the experimental group 2-3 in Example 2, under the same other conditions, molecularly imprinted polymer MIPs with different crosslinking agents were prepared. The MIP and NIP prepared by the linking agent were named eMIP and eNIP, respectively, and the MIP and NIP prepared by DVB as the crosslinking agent were named dMIP and dNIP. The morphology and structure of eMIP and dMIP are as follows: figure 1 As shown, the IF values ​​of the two molecularly imprinted polymers in different concentrations of sample solutions are as follows figure 2 shown.

[0069] combine figure 1 and figure 2 It can be seen that the molecularly imprinted polymers prepared by different cross-linking agents have different shapes and specificities. The dMIP obtained by DVB is spherical, and the specific surface area is smaller than that of eMIP obtained by EGDMA, but the specificity is stronger than eMIP. In the methylpyrimidine sta...

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Abstract

The invention discloses a synthesis method and application of a sulfonamide dimethylpyrimidine molecularly imprinted polymer. The synthesis method comprises the steps: adopting sulfamethazine as a template molecule, adopting methacrylic acid and diallylamine as mixed functional monomers and divinylbenzene as a cross-linking agent under the condition of a methanol solvent, and performing a precipitation polymerization reaction in a constant-temperature bath under the action of an initiator so as to prepare the sulfonamide dimethylpyrimidine molecularly imprinted polymer. The sulfonamide dimethylpyrimidine molecularly imprinted polymer has a good recognition ability for SMZ, the effects of separation and enrichment of SMZ are achieved through specific SMZ adsorption, and good specific adsorption abilities are achieved.

Description

technical field [0001] The invention belongs to the technical field of chemical detection, and in particular relates to a synthesis method and application of a sulfonamide-type dimethylpyrimidine molecularly imprinted polymer. Background technique [0002] Sulfonamides (Sulfanilamide, SAs) contain p-aminobenzamide, which can inhibit the reproduction of bacteria by competing with aminobenzoic acid for dihydrofolate synthase. It is a chemically synthesized artificial antibacterial agent. Treatment, animal husbandry and even a part of aquaculture have applications, mostly used in animal husbandry production as veterinary drugs, but due to the abuse and general use of sulfa drugs, drug pollution is becoming more and more serious, causing cross-resistance of microorganisms, microbial Antibacterial enhancement and other issues. Many countries have developed testing plans on this issue, and clearly require the maximum residue level (MRL) of sulfonamide antibiotics to be 100 μg / kg....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F226/04C08F220/06C08F212/36B01J20/26B01J20/30C02F1/28B01D15/08G01N1/40G01N30/02G01N33/15C02F101/38
CPCB01D15/08B01J20/268C02F1/285C02F2101/38C02F2101/40C08F220/06C08F226/04G01N1/405G01N30/02G01N33/15C08F212/36
Inventor 韦晓群李心悦李劼吴晓彤单惠芬张敏婕徐振林雷红涛孙远明
Owner SOUTH CHINA AGRI UNIV
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