Interactive parameterized three-dimensional DNA conformation simulation method for secondary school teaching

Abstract

The invention relates to an interactive parameterized three-dimensional DNA conformation simulation method for secondary school teaching, a double linked list is used as an underlayer data structure to generate a DNA base sequence fragment single chain 1 # and another single chain 2 # which is matched with the DNA base sequence fragment single chain 1 # but contains errors, the polarity directionof the single chain 2 # and the base complementary pairing error are interactively corrected , and a DNA primary structure is simulated; on the basis, the type of DNA is interactively selected, a local reference frame of a double-helix secondary structure is calculated, the dynamic process of spiraling while stacking of DNA base pairs is simulated according to the reference frame, and each secondary structure parameter is displayed on a three-dimensional model; and the local reference frame is updated by interactively editing a space curve, so that linear DNA double-chains are bent and wound in the space, and various superhelix high-level structures of the DNA from a linear shape and a bent shape to any zigzagging wound shape are simulated. According to the interactive parameterized three-dimensional DNA conformation simulation method for secondary school teaching in the invention, the DNA conformation can be simulated and displayed in an interactive mode, and the understanding and recognition of students on the DNA conformation can be accelerated and deepened.

Description

technical field [0001] The invention relates to the fields of computer simulation and education, in particular to an interactive parametric simulation method of three-dimensional DNA conformation for middle school teaching. Background technique [0002] The spatial structure of DNA molecules is an important content of high school biology courses. A single deoxynucleotide chain cannot exist stably. So what kind of structure does a DNA molecule composed of such long chains need to have in order to exist stably and be passed on to future generations? In addition, how biomacromolecules achieve highly specific interactions between biomolecules through the specific spatial arrangement (also called conformation) of the constituent atoms of DNA molecules, which is of great significance for understanding the structure and function of biomolecules in inquiry learning. [0003] In-depth understanding and understanding of the spatial arrangement of the constituent atoms of DNA molecules...

AI Technical Summary

Problems solved by technology

However, limited by technology, 3D genome research is still in the descriptive stage, and it is impossible to give a comprehensive explanation of how the geometric structure of DNA determines biological functions.

[0006] Existing studies on the geometric structure of DNA space need to calculate the change of energy to determine the different conformations of the geometric structure of DNA space, focusing on complex numerical calculations, which are poor intuition and operability

In the existing technology, OpenGL is used for simulation, but the DNA winding model is directly simulated by inputting equations, which leads to low user participation and poor interactivity

In addition, the existing relevant DNA materials used in middle school teaching are mainly schematic diagrams and videos, and the descriptions involving DNA conformation are not only rough but also scarce, not only unable to clearly present the microscopic geometric structure of DNA molecules, but also unable to explain the three-dimensional The relationship between geometric structure and biological function

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