Anti-interference small animal electroencephalogram collecting and recording device

Abstract

The invention discloses an anti-interference small animal electroencephalogram collecting and recording device, and belongs to the technical field of brain science experiments. The anti-interference small animal electroencephalogram collecting and recording device comprises an inhaled anesthesia module, an electroencephalogram recording and fixing module and a bioelectrical signal collecting module; the inhaled anesthesia module is composed of a small animal breathing mask, an anaesthesia machine and a medical oxygen bottle; the electroencephalogram recording and fixing module comprises a fixed base, a breathing mask lifting device, an auxiliary head platform, a fixing ring bracket lifting device, a brain electrode fixing ring bracket, a fixed barrel supporting table and a small animal body fixing barrel, wherein the breathing mask lifting device, the auxiliary head platform, the fixing ring bracket lifting device, the brain electrode fixing ring bracket, the fixed barrel supporting table and the small animal body fixing barrel are arranged on the fixed base; and the bioelectrical signal collecting module comprises a bioelectrical signal recording device and an electroencephalogramsignal leading electrode connected to the bioelectrical signal recording device. According to the anti-interference small animal electroencephalogram collecting and recording device, the head and a body of a mouse are fixed through inhalation anesthesia, so that electroencephalograms are collected, and interference electrical signals generated during breathing and moving of the mouse are avoided.

Description

technical field [0001] The invention belongs to the technical field of brain science experiments, and in particular relates to an anti-interference small animal EEG collection and recording device. Background technique [0002] The electroencephalogram records the spontaneous and rhythmic electrical activity of brain cell groups through electrodes, so as to analyze diseases and provide diagnostic basis. In particular, it can be used to dynamically observe the formation and seizure process of epilepsy, which is helpful for the development and research of epilepsy drugs. Repeated acquisition of EEG from the same animal not only reduces the use of experimental animals, but also effectively avoids the problem of individual differences among different animals in the group. At present, in animal experiments, brain electrodes are directly connected to a biological signal recording system or the recording electrodes, signal receivers and transmitters are fixed on the skull together...

AI Technical Summary

Problems solved by technology

For larger animals such as rats and guinea pigs, it only brings inconvenience and a decrease in comfort. For smaller experimental animals such as mice, it may even affect their main activities such as eating and drinking and give their heads bring greater pressure

Because the head of rats or mice is small and has a special structure, similar to a cone, it is inconvenient for inspectors to install the EEG device, which is time-consuming and labor-intensive.

When the EEG device used is installed on the skull of a rat or mouse, the relevant parts of the EEG device are easy to fall off because the rat or mouse likes to move, which interferes with the collection of EEG signals, and the rat or mouse is sensitive Type animals, when the head feels uncomfortable, will use the minions to constantly move the EEG acquisition device. When the EEG acquisition device is not moved by the minions, the interference effect is large, which is not conducive to the acquisition of EEG signals.

In addition, the brain electrodes are directly connected to the biosignal recording system, and the animal electrodes are easy to detach. During the recording, the electrode movement caused by the animal's breathing or the interference electrical signals generated by the muscle contraction have a large interference effect, which is not conducive to the acquisition of EEG signals, and will die after continuing anesthesia. high rate

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