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Traditional Chinese medicinecomposition containing recombinant hirudin suitable for eyes and preparation method

A technology of recombinant hirudin and composition, which is applied in the direction of drug combination, medical preparation containing active ingredients, pharmaceutical formula, etc., which can solve the problems of tear film damage and aggravation of symptoms, and achieve the improvement of eye fatigue symptoms, improvement and relief of vision The effect of obstacles

Pending Publication Date: 2020-01-03
云山化妆品研究开发(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And many people buy eye drops and other eye medicines and skin care products by themselves in order to quickly relieve symptoms, and these skin care products are mixed, most of which contain antibiotics and preservatives, which will further damage the tear film, aggravate symptoms, and form a vicious circle

Method used

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  • Traditional Chinese medicinecomposition containing recombinant hirudin suitable for eyes and preparation method
  • Traditional Chinese medicinecomposition containing recombinant hirudin suitable for eyes and preparation method

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preparation example Construction

[0035] In a preferred embodiment, the preparation method of recombinant hirudin, wherein, the preparation process of recombinant hirudin includes: placing the seed liquid in the initial medium, passing through sterile air, and keeping the DO value greater than 40%; When the DO value is greater than 55%, the feed medium is added dropwise to the initial medium by feeding.

[0036] In one embodiment, the ventilation rate of the sterile air is 3-7 L / min; preferably, the ventilation rate of the sterile air is 5 L / min.

[0037] In one embodiment, the temperature of the initial medium is 25-40°C; preferably, the temperature of the initial medium is 27-35°C; more preferably, the temperature of the initial medium is 30°C.

[0038] In one embodiment, the preparation process of recombinant hirudin is carried out under conventional or well-known devices and conditions in the art.

[0039] In one embodiment, the preparation process of recombinant hirudin is carried out in a shake flask at a...

Embodiment 1

[0169] Embodiment 1 of the present invention provides a traditional Chinese medicine composition suitable for eyes containing recombinant hirudin, comprising 1.5% oil phase component, 0.5% solubilizer, 8% recombinant hirudin fermented liquid, 1.2% of traditional Chinese medicine components and the rest of the water phase components;

[0170] The oil phase components include humectant and sodium hyaluronate, and the weight ratio of humectant to sodium hyaluronate is 1:0.1;

[0171] The humectant is xylitol and xanthan gum, and the weight ratio of xylitol and xanthan gum is 1:0.3;

[0172] Xylitol substances were purchased from French SEPPIC company, AQUAXYL xylitol;

[0173] Solubilizer is oleth, oleth includes oleth-12, oleth-15, oleth-20, oleth-12, oleth-15, oleyl alcohol The weight ratio of polyether-20 is 1:1:1;

[0174] The raw materials for the preparation of traditional Chinese medicine components include wild chrysanthemum, mulberry leaves, cassia seeds, Phellodendro...

Embodiment 2

[0210] Embodiment 2 of the present invention provides a traditional Chinese medicine composition suitable for eyes containing recombinant hirudin, comprising 3% oil phase components, 0.8% solubilizer, 15% recombinant hirudin fermented liquid, 2% of traditional Chinese medicine components and the rest of the water phase components;

[0211] The oil phase components include humectant and sodium hyaluronate, and the weight ratio of humectant to sodium hyaluronate is 1:0.3;

[0212] The humectant is xylitol and xanthan gum, and the weight ratio of xylitol and xanthan gum is 1:0.5;

[0213] Xylitol substances were purchased from French SEPPIC company, AQUAXYL xylitol;

[0214] Solubilizer is oleth, oleth includes oleth-12, oleth-15, oleth-20, oleth-12, oleth-15, oleyl alcohol The weight ratio of polyether-20 is 1:1.2:1.2;

[0215] The raw materials for the preparation of traditional Chinese medicine components include wild chrysanthemum, mulberry leaves, cassia seeds, Phellodend...

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Abstract

The invention relates to the technical field of eye treatment, in particular to a traditional Chinese medicine composition containing recombinant hirudin suitable for eyes, preparations, preparation method and application. The traditional Chinese medicine composition containing the recombinant hirudin suitable for the eyes is prepared from the components in percentage by weight: 1-3% of oil phasecomponents,0.3-0.8% of a solubilizer, 5-15% of recombinant hirudin fermentation broth, 0.8-2% of traditional medicine components and the balance of residual water phase components. The traditional Chinese medicine composition can relieve and treat eye fatigue and dry eye diseases, can improve and alleviate visual impairment, symptoms of the eye fatigue with dry sensation, foreign body sensation, cautery sensation, itchy sensation, low light, eye redness, blurred vision, visual fluctuation and eye pain irritation are improved. In addition, eye skin black circles, fish tail lines, pouch, swelling and other symptoms are further alleviated and eliminated.

Description

technical field [0001] The present invention relates to the technical field of eye treatment, more specifically, the present invention provides a traditional Chinese medicine composition, preparation, preparation method and application suitable for eyes containing recombinant hirudin. Background technique [0002] Eye fatigue and dry eye syndrome are common ocular surface diseases that increasingly affect people's quality of life. With the accelerated pace of life and increased pressure of study and work, the widespread popularization of electronic products among college students, the development of poor eye use and living habits, more and more people complain of "eye fatigue", and video terminal syndrome (VDT) appears The number of college students with symptoms is also increasing day by day, and the incidence of dry eye is gradually increasing. In recent years, the incidence of dry eye in my country has been increasing year by year and is developing towards a younger age....

Claims

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Application Information

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IPC IPC(8): A61K38/58A61P27/02A61K31/045A61K33/30A61K35/618A61K36/21A61K36/23A61K36/236A61K36/286A61K36/287A61K36/482A61K36/533A61K36/534A61K36/537A61K36/54A61K36/56A61K36/605A61K36/63A61K36/756A61K36/815A61K36/88A61K36/8968A61K36/8969A61K36/8984
CPCA61K38/58A61K36/287A61K36/605A61K36/482A61K36/756A61K35/618A61K33/30A61K36/533A61K36/286A61K36/236A61K36/537A61K36/8984A61K36/54A61K36/534A61K36/88A61K36/21A61K31/045A61K36/815A61K36/23A61K36/8968A61K36/8969A61K36/56A61K36/63A61P27/02A61K2300/00
Inventor 杨爱岗胡云山
Owner 云山化妆品研究开发(广州)有限公司
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