Preparation method of polyhydroxyalkanoate/polypyrrole composite electrospun membrane and electrospun membrane

A polyhydroxyalkanoate and electrospinning technology, which is applied in the field of medical biomaterials, can solve the problems of indeterminate properties, difficult to implement molding processes, complicated preparation methods, etc., achieves high universality in application scope, and is conducive to cell adhesion. The effect of simple growth and preparation process

Active Publication Date: 2020-01-17
MEDPHA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the material is insoluble in water, and it is difficult to realize the conventional molding process. It is possible to obtain ideal nano-scale fibers through organic solvent dissolution and electrospinning process.
Existing patent technology discloses polyhyd

Method used

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  • Preparation method of polyhydroxyalkanoate/polypyrrole composite electrospun membrane and electrospun membrane
  • Preparation method of polyhydroxyalkanoate/polypyrrole composite electrospun membrane and electrospun membrane
  • Preparation method of polyhydroxyalkanoate/polypyrrole composite electrospun membrane and electrospun membrane

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Embodiment 1

[0028] A polyhydroxyalkanoate / polypyrrole composite electrospun membrane, its preparation process is as follows:

[0029] A preparation method of polyhydroxyalkanoate / polypyrrole composite electrospun membrane, comprising the steps of:

[0030] S1. Preparation of polyhydroxyalkanoate (PHA) nanofiber electrospun membrane: Weigh 1g of medical-grade PHA powder and dissolve it in 10mL of dichloromethane and dimethylformamide composite solvent (dichloromethane and dimethylformamide The volume ratio of formamide is 3:7), uniformly stirred to form a PHA solution with a concentration of 100mg / mL and added to a 1mL syringe, and the syringe was fixed with a needle nozzle. At room temperature, the distance between the needle and the receiver was set to 15 cm, the voltage was 15 kV, and the syringe advancing speed was 3.0 ml / hour, and the electrofilament was collected through ethanol solution. Subsequently, the obtained electrolike silk was washed three times with deionized water, and po...

Embodiment 2

[0033] A preparation method of polyhydroxyalkanoate / polypyrrole composite electrospun membrane, comprising the steps of:

[0034] S1. Preparation of polyhydroxyalkanoate (PHA) nanofiber electrospun membrane: Weigh 0.95g of medical-grade PHA powder and dissolve it in 10mL of dichloromethane and dimethylformamide composite solvent (dichloromethane and dimethylformamide The volume ratio of methyl formamide is 3:7), uniformly stirred to form a PHA solution with a concentration of 100mg / mL and added to a 1mL syringe, and the syringe was fixed with a needle nozzle. At room temperature, the distance between the needle and the receiver was set to 15 cm, the voltage was 15 kV, and the syringe advancing speed was 3.0 ml / hour, and the electrofilament was collected through ethanol solution. Subsequently, the obtained electrolike silk was washed three times with deionized water, and polyhydroxyalkanoate nanofibers were obtained after freeze-drying overnight. The above-mentioned nanofibers...

Embodiment 3

[0037] A preparation method of polyhydroxyalkanoate / polypyrrole composite electrospun membrane, comprising the steps of:

[0038] S1. Preparation of polyhydroxyalkanoate (PHA) nanofiber electrospun membrane: Weigh 1.05g of medical-grade PHA powder and dissolve it in 10mL of dichloromethane and dimethylformamide composite solvent (dichloromethane and dimethylformamide The volume ratio of methyl formamide is 3:7), uniformly stirred to form a PHA solution with a concentration of 100mg / mL and added to a 1mL syringe, and the syringe was fixed with a needle nozzle. At room temperature, the distance between the needle and the receiver was set to 15 cm, the voltage was 15 kV, and the syringe advancing speed was 3.0 ml / hour, and the electrofilament was collected through ethanol solution. Subsequently, the obtained electrolike silk was washed three times with deionized water, and polyhydroxyalkanoate nanofibers were obtained after freeze-drying overnight. The above-mentioned nanofibers a...

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Abstract

The invention discloses a preparation method of a polyhydroxyalkanoate/polypyrrole composite electrospun membrane and an electrospinning membrane; the preparation method comprises the steps of preparing a polyhydroxyalkanoate fiber electrospun membrane through an electrospinning process, and then preparing the polyhydroxyalkanoate/polypyrrole composite electrospun membrane through a surface modification process. The preparation method is simple and rapid, raw materials are easy to obtain, and the prepared polyhydroxyalkanoate/polypyrrole composite electrospun membrane has good hydrophilicity and cell compatibility, can provide durable and stable skeleton structure supporting after being implanted into tissues, can regulate cell attachment and cell migration and induce tissue differentiation under electrical stimulation, and has wide application prospects in the bioengineering fields such as oriented repair of tissue.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a method for preparing a polyhydroxyalkanoate / polypyrrole composite electrospun membrane. Background technique [0002] Electrospinning is a special fiber manufacturing process. The polymer solution is jet-spun under the action of a strong electric field to obtain nano-scale fiber filaments. Its fibrous structure can mimic the structure and biological function of natural extracellular matrix, and its potential applications include drug-loaded scaffolds, tissue and organ repair scaffolds, and more. However, the types of polymer molecules that can be used for electrospinning are limited, the structure is easily damaged by external forces, and the mechanical properties and biocompatibility are often unsatisfactory. [0003] In recent years, a class of polymer materials obtained by microbial fermentation has attracted widespread attention. It is called Polyhydroxyalkanoates (PHA)...

Claims

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Application Information

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IPC IPC(8): D04H1/435D06B13/00D01D5/00D01F6/92D06M15/37D06M101/32
CPCD01D5/003D01D5/0061D01D5/0092D01F6/92D04H1/435D06B13/00D06M15/37D06M2101/32
Inventor 吕金艳
Owner MEDPHA CO LTD
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