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Ocular extractives injection, as well as preparation method and application thereof

A technology for ophthalmic aminopeptide and injection, applied in the field of ocular aminopeptide injection and its preparation, can solve the problems of providing many process steps, low ocular aminopeptide content, and large investment

Active Publication Date: 2020-01-24
HUBEI WEISHI BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the extraction process of eye aminopeptide, the existing technology mostly adopts alcohol extraction, activated carbon adsorption, decolorization and other steps to obtain it. There are many process steps and large investment, and the content of eye aminopeptide in the extracted product is low

Method used

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  • Ocular extractives injection, as well as preparation method and application thereof
  • Ocular extractives injection, as well as preparation method and application thereof
  • Ocular extractives injection, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0017] One, the preparation of eye aminopeptide injection

[0018] The invention provides a preparation method of eye aminopeptide injection, which comprises the steps of: preparing pig eyeballs through extraction, adsorption, refining and post-treatment.

[0019] Initial extraction: take pig eyeballs, smash them and extract with ethanol solution, filter the extract to obtain the first filtrate and the first residue; the first filter residue is leached with ethanol solution again and then filtered to obtain the second filtrate and the second residue. Residue; the second filter residue is leached again with purified water and filtered to obtain the third filtrate and the third residue, the first filtrate, the second filtrate and the third filtrate are combined to obtain a combined liquid; the extraction is carried out by passing the pig's eyeball through ethanol twice Solution extraction and one-time extraction with purified water can repeatedly extract ophthalmic aminopeptides...

Embodiment 1

[0031] Embodiment 1: 300 parts of eye aminopeptide, 400 parts of calcined gypsum, 10 parts of vitamins, 100 parts of xuanming powder, 30 parts of borneol, 100 parts of astragalus, and 3000 parts of water of embodiment 1. The medicament is a suspension.

Embodiment 2

[0032] Embodiment 2: 100 parts of eye aminopeptides, 600 parts of calcined gypsum, 20 parts of vitamins, 800 parts of xuanming powder, 20 parts of borneol, 180 parts of astragalus, and 3000 parts of water of embodiment 1. The medicament is a suspension.

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Abstract

The invention discloses an ocular extractives injection, as well as a preparation method and application thereof. The preparation method comprises the following steps of adopting pig eyeballs, pounding, extracting through an ethanol solution for two times, extracting pure water for one time, filtering after extracting, and merging filtrates so as to obtain merging liquid; concentrating the mergingliquid, heating until boiling, filtering, and after carrying out activated carbon adsorption treatment and titanium stick filter treatment on filter liquor, cooling the filter liquor to obtain cooling liquid; carrying out ultrafiltration treatment on the cooling liquid, collecting permeate liquid, carrying out affinity chromatography treatment, and collecting eluant of target components; and after concentrating the eluant, blending, filling-sealing, and sterilizing to obtain the ocular extractives injection. The ocular extractives injection is applied to preparing a composition drug for treating recurrent aphthae. According to the ocular extractives injection, as well as the preparation method and the application thereof provided by the invention, through controlling the process parameters of the preparation method, the peptide content in the prepared ocular extractives injection reaches up to 79.2 percent; and the recurrent aphthae curing effect test shows that the composition drug prepared through the ocular extractives injection has a medicinal effect on treating recurrent aphthae.

Description

technical field [0001] The invention relates to the technical field of composition medicaments, in particular to an eye aminopeptide injection and its preparation method and application. Background technique [0002] Recurrent aphth is a common disease of oral mucosal lesions caused by multiple factors. It is caused by factors such as common cold, indigestion, mental stress, and depression, and has a certain recurrence. Generally, the main symptoms are aphthous ulcers, which are self-limiting and self-healing within 10 days. The specific mechanism is not clear. There is currently a lack of effective treatment options. Pathogenic factors may also be related to α-hemolytic L-type streptococcal infection, digestive system diseases, mental factors, endocrine disorders, iron deficiency, zinc deficiency, folic acid, and vitamins. [0003] Eye aminopeptides are extracted from pig eyeballs or bovine eyeballs, which are rich in amino acids, polypeptides, nucleotides and trace eleme...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K35/30A61K9/10A61P1/02A61K31/045A61K31/07A61K31/714A61K33/04A61K33/06
CPCA61K9/0019A61K9/10A61K31/045A61K31/07A61K31/714A61K33/04A61K33/06A61K35/30A61K36/481A61P1/02A61K2300/00
Inventor 罗先隽
Owner HUBEI WEISHI BIO PHARMA
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