A kind of purification method of nicotine and nicotine

A purification method and technology of nicotine, which is applied in the field of purification of natural products, and can solve the problems of heavy chemical odor, yellowish color and unstable properties of nicotine

Active Publication Date: 2021-02-09
上海零诺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large amount of organic solvents will be used in the extraction process, and solvent residues (such as petroleum ether, etc.) are inevitable. Since the current industrial production of nicotine uses simple distillation or rectification processes, the operating temperature is above 100 ° C, and it is unavoidable to mix Oxygen component, while the nature of nicotine itself is unstable, the action of high temperature and oxygen will cause the cracking of residual organic solvents and the oxidation and degradation of nicotine itself. The purity of the finished nicotine thus obtained is generally between 95% and 97%. , and the color is yellowish, the appearance is not good, and the nicotine produced by conventional industrial methods is found to have a heavy chemical odor during the application of electronic cigarettes, which limits the application of nicotine in the field of biomedicine

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  • A kind of purification method of nicotine and nicotine
  • A kind of purification method of nicotine and nicotine
  • A kind of purification method of nicotine and nicotine

Examples

Experimental program
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Effect test

Embodiment 1

[0047] The purification method of nicotine of the present embodiment comprises the following steps:

[0048] 1) Put 25L nicotine into a 30L rectification reaction kettle, set the temperature at 90°C, carry out under normal pressure, set the reflux ratio to full outflow, keep the nicotine in the reaction kettle without boiling, and use a blower device to continuously ventilate Inject nitrogen, keep a certain amount of fresh nitrogen circulating in the rectification equipment, and continue for 3 hours, so that low-boiling substances such as organic solvents are continuously heated and volatilized, and flow out with the airflow;

[0049] 2) The nicotine after atmospheric distillation is divided into two steps for vacuum distillation. The first step of distillation raises the rectification temperature to 110°C, the vacuum degree is 0.08Mpa, the reflux ratio is set to full outflow, and the distillation time is 40min. There is no obvious oil on the wall of the glass tube (residual o...

Embodiment 2

[0069] The purification method of nicotine of the present embodiment comprises the following steps:

[0070] 1) Put 25L of nicotine into a 30L rectification reaction kettle, set the temperature at 100°C, carry out under normal pressure, set the reflux ratio to full outflow, keep the nicotine in the reaction kettle from boiling, and use a blower device to continuously ventilate Inject nitrogen, and keep a certain amount of fresh nitrogen circulating in the rectification equipment for 4 hours, so that low-boiling substances such as organic solvents are continuously heated and volatilized, and flow out with the airflow;

[0071] 2) The nicotine after atmospheric distillation is divided into two steps for vacuum distillation. The first step of distillation raises the rectification temperature to 120°C, the vacuum degree is 0.085Mpa, and the distillation time is 1h. At this time, there is no obvious oil on the glass tube wall The residual nicotine (residual organic solvents such as...

Embodiment 3

[0076] The purification method of nicotine of the present embodiment comprises the following steps:

[0077] 1) Put 25L of nicotine into a 30L rectification reaction kettle, set the temperature at 100°C, carry out under normal pressure, set the reflux ratio to full outflow, keep the nicotine in the reaction kettle from boiling, and use a blower device to continuously ventilate Inject argon, keep a certain amount of fresh nitrogen circulating in the rectification equipment, and continue for 5 hours, so that the organic solvent and other low boiling point substances are continuously heated and volatilized, and flow out with the air flow;

[0078] 2) The nicotine after atmospheric distillation is divided into two steps for vacuum distillation. The first step of distillation raises the rectification temperature to 150°C, the vacuum degree is 0.085Mpa, and the distillation time is 30min. At this time, there is no obvious oil on the glass tube wall The residual nicotine (residual or...

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Abstract

The invention relates to a nicotine purification method and nicotine. The nicotine purification method comprises the following steps: under the condition of introducing protective gas, carrying out atmospheric distillation on nicotine to be treated at 90-100 DEG C to remove low-boiling-point impurities; after atmospheric distillation, carrying out vacuum distillation on the treated nicotine in twosteps, wherein in the first step, vacuum distillation is carried out at 110-150 DEG C for 30 min to 1 h to obtain a small amount of nicotine which is discarded, and nicotine which is not distilled isobtained; in the second step, nicotine which is not distilled is distilled again at 120-150 DEG C, and nicotine is obtained; and carrying out reduced pressure distillation on the nicotine obtained inthe second step of vacuum distillation to obtain the required nicotine. The nicotine treated by the method is high in purity, is a transparent and colorless liquid, is purer in smell, and does not contain residual chemical odor in common nicotine products; and the related operation requires less labor, the treatment amount is large, the average daily nicotine treatment amount can reach 100 L, andthe method is suitable for large-scale production and use.

Description

technical field [0001] The invention relates to the technical field of purification of natural products, in particular to a method for purifying nicotine and nicotine. Background technique [0002] Nicotine, commonly known as nicotine, is an important chemical raw material in the pharmaceutical, pesticide and chemical industries. According to research, nicotine has obvious curative effects on Alzheimer's disease and depression, and has great application potential in the field of treatment of related diseases, and its demand is large , the price of high-purity nicotine at home and abroad is more than 500,000 to 1,000,000 per ton. At present, nicotine is mainly extracted from tobacco and or discarded tobacco stems and tobacco leaves. [0003] Nicotine is easily soluble in alcohol, ether, chloroform, alkanes and other organic solvents as well as in water. At present, the industrial production and preparation of nicotine mainly uses extraction equipment to extract in lye and ac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D401/04
CPCC07D401/04
Inventor 潘学连董磊沈兆元
Owner 上海零诺生物科技有限公司
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