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Herpes simplex virus relevant antigen short chain polypeptide and application thereof

A herpes simplex virus and short peptide technology, applied in the field of biomedicine, can solve the problems of inability to effectively prevent the activation of latent virus, no effective vaccine, inability to clear the virus, etc., to achieve enhanced immune control effect, good clinical transformation and practical application prospects , the effect of precise long-term immune memory

Inactive Publication Date: 2020-01-24
维塔恩(广州)医药有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the prevention of its infection is mainly to avoid contact with active HSV infection, such as antiviral drugs acyclovir and ganciclovir, etc., but none of them can clear the virus in the state of latent infection or prevent latent infection
[0004] Although HSV antibodies cannot effectively prevent the activation of latent virus, they can alleviate the disease
HSV currently has no effective vaccine

Method used

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  • Herpes simplex virus relevant antigen short chain polypeptide and application thereof
  • Herpes simplex virus relevant antigen short chain polypeptide and application thereof
  • Herpes simplex virus relevant antigen short chain polypeptide and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Dendritic Cell therapy technology (Dendritic Cell, DC) is to collect autologous peripheral blood mononuclear cells, add specific cytokines in a strict aseptic environment, and at the same time supplement with stem cell factor / vitrogen factor to obtain more active transformed cells. Dendritic cell (DC) with antigen presenting function. HSV antigen peptides were added the day before reinfusion. DCs recognized and captured a variety of single-epitope antigen peptides to obtain mature dendritic cells sensitized by specific antigen peptides of high-risk pathogenic viruses. Immunological activity can induce the body to produce a large number of antibodies against specific antigens, thereby rebuilding the immune balance of the body, so that by preventing and controlling pathogenic virus infection, the prevention of pathogenic microorganisms is more targeted and active, and fundamentally prevents herpes simplex virus-related chronic diseases happened.

[0043]The purpose of th...

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PUM

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Abstract

The invention discloses herpes simplex virus relevant antigen short chain polypeptide and an application thereof. The sequence of the herpes simplex virus relevant antigen short chain polypeptide is as shown in any of SEQID NO:1-16. The short chain polypeptide has high affinity with MHC I type molecules and MHCII molecules on DC cells, can effectively enable the MHC I type molecules and the MHCIImolecules on the DC cells to achieve the antigen presentation effects, and has favorable potential of a polypeptide vaccine and favorable potential of a DC vaccine. The DC vaccine prepared from one ormore in vitro sensitization dendritic cells in the short chain polypeptide can prevent herpes simplex virus relevant diseases, so that the short chain polypeptide has favorable clinical transformation prospects. Besides, the antigen short chain polypeptide is short in length and small in chemical synthesis difficulty, high-purity products can be obtained through direct synthesis of the antigen short chain polypeptide, the application cost is greatly reduced, besides, the effects are definite, and the antigen short chain polypeptide has good application prospects.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to short peptides of herpes simplex virus-associated antigens and applications thereof. Background technique [0002] Human simplex virus (HSV). HSV has a wide host range, is widely distributed in the population, has a high infection rate, and can proliferate in various cells in the human body. The HSV genome is about 150 KB and can encode at least 70 kinds of proteins, including at least 11 shell glycoproteins. , which play a crucial role in viral replication and pathogenesis. HSV infection is typically characterized by vesicles of skin lesions, which can also harbor latent infection in nerve cells. It has been confirmed that HSV can cause a variety of chronic diseases. HSV-2 is a high-risk factor for hypertension, and the infection rate of HSV in patients with hypertension is higher; it can also promote fat deposition in smooth muscle cells; patients with Al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/08A61K39/245A61P31/22
CPCA61K39/12A61K2039/5154A61K2039/55522A61P31/22C07K7/08C12N2710/16634
Inventor 黄燕花赵乙木罗夫·辛克纳吉孙晨
Owner 维塔恩(广州)医药有限公司
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