Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Chlamydiae-related antigen short chain polypeptide and application thereof

A Chlamydia pneumoniae and short peptide technology, which is applied in the field of biomedicine, can solve problems such as weak immunity and long-lasting immunity, and achieve the effects of increasing commission capacity, reducing application costs, good clinical transformation and practical application prospects

Inactive Publication Date: 2020-02-04
维塔恩(广州)医药有限公司
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chlamydia pneumoniae infection can induce the body to produce specific humoral immunity and cellular immunity, and specific antibodies can block its adsorption to host cells, but its immunity is often not durable and not strong
Chlamydia pneumoniae currently has no effective vaccine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chlamydiae-related antigen short chain polypeptide and application thereof
  • Chlamydiae-related antigen short chain polypeptide and application thereof
  • Chlamydiae-related antigen short chain polypeptide and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043]Dendritic Cell therapy technology (Dendritic Cell, DC) is to collect autologous peripheral blood mononuclear cells, add specific cytokines in a strict aseptic environment, and at the same time supplement with stem cell factor / vitrogen factor to obtain more active transformed cells. Dendritic cell (DC) with antigen presenting function. Chlamydia pneumoniae antigen peptides were added the day before the reinfusion, and DCs recognized and captured multiple single-epitope antigen peptides to obtain mature dendritic cells sensitized by specific antigen peptides of high-risk pathogenic viruses, and used the ability of dendritic cells to target migration and immune activity, which can induce the body to produce a large number of antibodies against specific antigens, and then rebuild the immune balance of the body, so that by preventing and controlling pathogenic virus infection, the prevention of pathogenic microorganisms is more targeted and active, and fundamentally prevents C...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a chlamydiae antigen short chain polypeptide and application thereof. The sequence of the chlamydiae antigen short chain polypeptide is shown as any one of SEQ ID NO:1-16. Theshort chain polypeptide has high affinity to MHC I and MHC II molecules on dendritic cell (DC) cells, can effectively make the MHC I and MHC II molecules achieve an antigen presentation effect, and has good polypeptide vaccine and DC vaccine potential. DC vaccines prepared from at least one in-vitro sensitized dendritic cell in the short chain polypeptide can prevent chlamydiae-related diseases, especially related chronic diseases, and have good clinical transformation prospects. Moreover, the length of the antigen short chain polypeptide is small, the chemical synthesis difficulty is small, high-purity products can be obtained through direct synthesis, the application cost is greatly lowered, meanwhile, the effect is clear, and good application prospects are achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to short peptides of Chlamydia pneumoniae-associated antigens and applications thereof. Background technique [0002] From 1990 to 2013, life expectancy at birth increased by 6.2 years, according to The Lancet in 2015. As life expectancy increases, people are concerned not only with the extension of lifespan, but also with the improvement of quality of life. Disability caused by disease is one of the important reasons that affect the quality of life. At present, the number of disabilities caused by almost all causes in the world is declining, and only the number of disabilities caused by cardiovascular and cerebrovascular diseases and tumors has increased. Most chronic diseases such as cardiovascular and cerebrovascular diseases and tumors lack specific clinical symptoms in the early stage, and often develop into irreversible diseases when they are diagnosed. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/295A61K39/118A61P31/04
CPCA61K39/118A61P31/04C07K14/295
Inventor 黄燕花赵乙木罗夫·辛克纳吉孙晨
Owner 维塔恩(广州)医药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com