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Mupirocin ointment and preparation method thereof

A technology of mupirocin and ointment, applied in the field of mupirocin ointment and preparation, can solve the problem of high cost of raw materials, and achieve the effects of stable content, excellent release and reasonable viscosity

Inactive Publication Date: 2020-02-11
HUBEI HUMANWELL CHENGTIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the technical problem of high raw material cost of mupirocin ointment in the prior art, the invention provides a kind of mupirocin ointment and its preparation method

Method used

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  • Mupirocin ointment and preparation method thereof
  • Mupirocin ointment and preparation method thereof
  • Mupirocin ointment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take the raw material of mupirocin ointment by weighing following percentage by weight:

[0034] Macrogol-400: 78.4%, Macrogol-4000: 19.6%, Mupirocin: 2%.

[0035] The preparation method of mupirocin ointment comprises the following steps:

[0036] Step S1: Melt polyethylene glycol-400 and polyethylene glycol-4000 at a temperature of 65°C to 70°C to obtain a mixed blank matrix;

[0037] Step S2: After pulverizing mupirocin, pass through a 100-mesh sieve, add the mixed blank matrix and stir for 20 minutes, and simultaneously turn on the homogenizer to grind for 5 minutes, and the stirring speed is 60r / min to obtain the ointment precursor;

[0038] Step S3: cooling the ointment precursor at 40°C for testing and packaging to obtain the mupirocin ointment.

Embodiment 2

[0040] Take the raw material of mupirocin ointment by weighing following percentage by weight:

[0041] Macrogol-400: 77.2%, Macrogol-4000: 20.8%, Mupirocin: 2%.

[0042] The preparation method of mupirocin ointment comprises the following steps:

[0043] Step S1: Melt polyethylene glycol-400 and polyethylene glycol-4000 at a temperature of 65°C to 70°C to obtain a mixed blank matrix;

[0044] Step S2: After pulverizing mupirocin, pass through a 100-mesh sieve, add the mixed blank matrix and stir for 30 minutes, and simultaneously turn on the homogenizer to grind for 8 minutes, and the stirring speed is 60r / min to obtain the ointment precursor;

[0045] Step S3: cooling the ointment precursor at 38° C. for detection and packaging to obtain the mupirocin ointment.

Embodiment 3

[0047] Take the raw material of mupirocin ointment by weighing following percentage by weight:

[0048] Macrogol-400: 76%, Macrogol-4000: 22%, Mupirocin: 2%.

[0049] The preparation method of mupirocin ointment comprises the following steps:

[0050] Step S1: Melt polyethylene glycol-400 and polyethylene glycol-4000 at a temperature of 65°C to 70°C to obtain a mixed blank matrix;

[0051] Step S2: After pulverizing mupirocin, pass through a 100-mesh sieve, add the mixed blank matrix and stir for 30 minutes, and simultaneously turn on the homogenizer to grind for 8 minutes, and the stirring speed is 60r / min to obtain the ointment precursor;

[0052] Step S3: cooling the ointment precursor at 42° C. for detection and packaging to obtain the mupirocin ointment.

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Abstract

The present invention provides a mupirocin ointment and a preparation method thereof. The mupirocin ointment is composed of the following components in percentages by weight: 70-85% of polyethylene glycol-400, 10-28% of polyethylene glycol-4000 and 1-4% of mupirocin. Compared with the prior art, the mupirocin ointment has the following beneficial effects: (1) polyethylene glycol-4000 is used for replacing polyethylene glycol-3350, the medical-grade polyethylene glycol-4000 is easier to obtain, and cost of preparation raw materials is reduced; and (2) the mupirocin ointment is low in impurity content and has a release rate superior to that of products on the market.

Description

technical field [0001] The invention belongs to the field of drug production, and in particular relates to a mupirocin ointment and a preparation method. Background technique [0002] According to the quality standard of mupirocin ointment, this product is an ointment with a water-soluble base, and its base is polyethylene glycol. Refer to the instructions for use of the marketed drug Zhongmei Tianjin Smith Kline Pharmaceutical Co., Ltd., and its base is polyethylene glycol -400 and polyethylene glycol-3350. Polyethylene glycol is a high-molecular polymer synthesized by condensation of ethylene oxide and water. Due to different degrees of polymerization, it is divided into liquid, semi-solid, and solid PEGs. Mixing PEGs with different molecular weights in an appropriate proportion can produce a suitable consistency. matrix. This type of matrix is ​​anhydrous but strongly hydrophilic, easily soluble in water and easy to wash off, and can absorb aqueous secretions on the sur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/351A61K47/10A61P17/00A61P31/04A61P31/02
CPCA61K31/351A61K9/06A61K47/10A61K9/0014A61P17/00A61P31/04A61P31/02
Inventor 罗光明刘长国张甫
Owner HUBEI HUMANWELL CHENGTIAN PHARMA
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