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A kind of ring metal iridium complex probe and its preparation method and application
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An iridium complex and cyclometal technology, applied in the field of chemistry, can solve the problems of difficult real-time quantitative detection and difficult detection, and achieve the effects of high yield, good photostability and long fluorescence lifetime.
Active Publication Date: 2022-05-13
HUNAN UNIV OF SCI & TECH
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Problems solved by technology
[0003] h 2 S has a very important physiological role in the body, but for H in the body 2 The real-time quantitative detection of S is still a difficult problem
Traditional analytical techniques such as colorimetry and gas chromatography can only analyze the H produced in vivo 2 S for volumetric measurements, H for detection in living cells and animal tissues 2 S is still very difficult
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Embodiment 1
[0041] (1) Preparation of Ligand L:
[0042] 2-[(2,4-Dinitrophenyl)thio]benzoic acid (0.58g, 1.8mmol), 4-hydroxymethyl-4'-methyl-2,2'-bipyridine (0.3g , 1.5mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.34g, 1.8mmol) and 4-dimethylaminopyridine (0.037g, 0.3mmol) in Stir in dichloromethane for 24 hours, wash the reaction solution with water, concentrate the organic phase, and pass through column chromatography to obtain a yellow solid with a yield of 79.68%.
[0045] Under nitrogen protection, the [Ir(ppy) 2 Cl] 2 (0.11g, 0.1mmol) and ligand L (0.11g, 0.22mmol) in a mixed solvent (V DCM : V MeOH = 1:1) for 5 h under reflux...
Embodiment 2
[0051] Complex Ir1 and complex Ir2 pair H 2 Fluorescent response experiment of S
[0052] During the experiment, the PBS buffer solution was prepared from ultrapure water and corresponding salts, and the PBS buffer solution (pH=7.2) was blown with nitrogen to remove oxygen before the test.
[0053] The solution used for the test is V DMSO :V PBS = 3:7, the complex used in the test process was first prepared with 20mM mother solution in DMSO. other ion C 2 o 4 2- 、HSO 3 - 、SCN - , CO 3 2- , Cl - 、Br - 、HCO 3 - , SO 4 2- , S 2 o 3 2- , F - , SO 3 2- 、Ac - , NO 2 - , I - 、H 2 o 2 , is prepared with ultrapure water, and the ion concentration is 20mM, and all ion solutions are prepared now.
[0054] Iridium complexes with H 2 Time test of S reaction: Take 3 µL of probe solution, 997 µL of DDMSO, 1970 µL of PBS buffer, and 30 µL of HS - The solution is added into a cuvette, detected on a fluorescence spectrophotometer, and scanned at intervals until t...
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Abstract
The invention discloses a cyclometal iridium complex probe and its preparation method and application, and its general structural formula is shown in formula (II): . Compared with the prior art, the cyclometalated iridium complex probe of the present invention has the following characteristics: 1. High quantum yield, large Stokes shift, long fluorescence lifetime and good photostability; 2. The complex has multiple It can be modified with different ligands to achieve selective fluorescence response to target molecules; 3. It can be used as H 2 A ratiometric fluorescent probe for S, enabling the detection of H 2 Quantitative detection of S; 4. For H 2 S is characterized by high selectivity.
Description
technical field [0001] The invention belongs to the field of chemistry, and in particular relates to a ring metal iridium complex probe and a preparation method and application thereof. Background technique [0002] In nature, H 2 S is a foul-smelling gas with the smell of rotten eggs, which can be dissolved in water and mainly in the form of HS - exist. h 2 Once S is inhaled by the human body, it will quickly transfer to the lungs, which may lead to loss of human consciousness and irreversible damage to the nervous system, and even death. In recent years, more and more studies have shown that H 2 S plays an important role in the physiological and pathological processes of organisms, including regulating vascular tone, stimulating angiogenesis, and cardioprotective functions. In addition, abnormal concentrations of H 2 S levels are closely related to many human diseases, such as low levels of H 2 S is closely related to cognitive impairment in patients with Alzheimer'...
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