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Synthesis of anti-tumor compound and application of anti-tumor drug in multiple myeloma

A compound, myeloma cell technology, used in antitumor drugs, sexual diseases, bone diseases, etc., can solve the problems of toxic and side effects drugs, drug resistance, etc.

Active Publication Date: 2020-03-27
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs not only have toxic side effects on the body but also cause drug resistance

Method used

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  • Synthesis of anti-tumor compound and application of anti-tumor drug in multiple myeloma

Examples

Experimental program
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Embodiment 1

[0011] Synthesis of the compound of Example 1 The compound shown in formula I is synthesized using the following reaction formula:

[0012] .

[0013] Add 5-methoxytryptamine (3.0 mmol) to chloroform (20 mL) solution, add triethylamine (6.0 mmol) dropwise, stir for 5 min, add 3,5-bis(trifluoromethyl)phenyliso Thiocyanate (3.0 mmol). Stirred and refluxed for 8 hours, the mixed solution was cooled to normal temperature, filtered with a Buchner funnel, washed the filter cake three times with 30ml of ethanol each time, collected the filtrate, and suspended it to dryness, concentrated to dryness, and the solid obtained was passed through 95% ethanol ( 30 mL) and filtered to collect the white solid to obtain the final product.

[0014] The present invention also provides the use of the above compound or a pharmaceutically acceptable salt thereof in tumor suppression.

[0015] The compound prepared by the present invention or the pharmaceutically acceptable salt thereof has obvi...

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Abstract

The invention relates to an anti-tumor drug represented by a formula I and an application of the anti-tumor drug in tumor treatment drugs, and belongs to the technical field of anti-tumor pharmacy. The technical problem to be solved by the invention is to provide a compound of a tumor inhibitor. The compound comprises a compound as shown in the specification and pharmaceutically acceptable salt thereof, can be used as a tumor inhibitor and has certain anti-tumor activity. The formula I is shown in the specification.

Description

technical field [0001] The invention discloses the synthesis of a new type of antineoplastic drug and its application in tumor treatment. Studies have shown that the compound has a good inhibitory effect on human myeloma cell U266, and belongs to the technical field of tumor treatment drug discovery. basis for development. Background technique [0002] Multiple myeloma (MM) is a malignant plasma cell disease that belongs to the range of B lymphocytic lymphomas, and its tumor cells originate from plasma cells in the bone marrow, which are cells that develop to the final functional stage of B lymphocytes. It is characterized by abnormal proliferation of bone marrow plasma cells with overproduction of monoclonal immunoglobulin or light chain (M protein), and very few patients can be non-secretory MM that does not produce M protein. The clinical manifestations are diverse, mainly including anemia, bone pain, renal insufficiency, infection, bleeding, neurological symptoms, hyper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D209/14A61P35/00A61P11/00A61P19/00A61P15/00
CPCC07D209/14A61P35/00A61P11/00A61P19/00A61P15/00
Inventor 何俊王贯罗小娇李蓉李峰
Owner SICHUAN UNIV