Monoclonal antibody for anti-human CEA, a composition containing same and application thereof

A technology of antibody and antibody light chain, applied in the field of molecular biology and biology
CN101607985AActive Publication Date: 2009-12-23INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
1 Cites 44 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
Publication Date
2009-12-23

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a mouse monoclonal antibody of anti-human carcino-embryonic antigen (CEA) resisting colorectal neoplasm activity, prepared by a biological technology. The method comprise a method for detecting CEA family protein by utilizing the antigen-combining capacity specificity of the mouse monoclonal antibody CC4 of anti-human CEA and a neoplasm treatment method by utilizing the colorectal neoplasm activity. The antibody can be used for specifically recognizing the human CEA at molecular, cellular and texture levels and recognizing a special antigen epiposition widely distributed in the CEA family protein. The CC4 is specifically combined with colorectal neoplasm texture at the texture level and presents stronger capabilities of restraining neoplasm growth, neoplasm metastasis, neoplasm invasion in an animal model and at the cellular level. The antibody and detection and treatment methods based on the antibody can become an effective neoplasm diagnosis and treatment tool in basal research or clinical application.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the fields of molecular biology and biotechnology. Specifically, the present invention relates to an anti-human CEA mouse monoclonal antibody CC4, which can specifically bind colorectal cancer tissue and effectively inhibit the growth, migration and invasion of colorectal tumor cells at the animal model and cell level. CC4 can specifically recognize human CEA protein at the biochemical, cellular and tissue levels, and bind to an antigenic epitope conserved in CEA family proteins. Utilizing these characteristics, the antibody can be widely used in the clinical diagnosis and treatment of tumors expressing CEA or CEA family proteins. Background technique

[0002] Carcinoembryonic antigen (CEA) is one of the earliest tumor-associated antigens discovered by people. It was first discovered and reported in colon cancer tissue extracts by Gold P and Freedman SO in 1965 (Gold and Freedman 1965; Gold and Freedman1965). In 1966, Gold P...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More