SNP marker related to auxiliary diagnosis of Chinese non-small cell lung cancer and application thereof

Abstract

The invention relates to an SNP marker related to auxiliary diagnosis of Chinese non-small cell lung cancer and application thereof. The marker is rs2046210. According to the invention, a technical method for screening non-small cell lung cancer high-risk groups is provided at molecular biology and gene diagnosis levels. The method based on early research shows that the BPA exposure level and thers2046210 site jointly influence the non-small cell lung cancer susceptibility of the Chinese population. Genotyping is carried out by developing a high-sensitivity BPA level measurement platform andcarrying out ingenious primer and probe design for an rs2046210 site and thus the high-risk group of the non-small cell lung cancer can be identified; and the diagnosis of the non-small cell lung cancer patients are helped. The method is ingenious, simple and feasible, is accurate and reliable in result and can be popularized in hospitals at all levels; the assistance is provided for evaluation ofrisk of the non-small cell lung cancer; and the clinical screening and early intervention of the non-small cell lung cancer for the group of people are facilitated.

Description

technical field [0001] The invention relates to the fields of genetic engineering and tumor medicine, in particular to a SNP marker related to the auxiliary diagnosis of non-small cell lung cancer in China and its application. Background technique [0002] Lung cancer is a common malignant tumor that seriously threatens the health of the people in our country. Its morbidity and mortality rate rank first among malignant tumors in my country. Among them, non-small cell lung cancer is the most common pathological type of lung cancer, accounting for about 80%-85% of all lung cancers. At present, there is still a lack of effective screening methods and early diagnosis methods for lung cancer. If screening and early diagnosis can be carried out more accurately for high-risk individuals of lung cancer, the prognosis of patients can be significantly improved, and a large amount of medical expenses can be saved for the country. [0003] Bisphenol A (BPA) is a common type of environ...

AI Technical Summary

Problems solved by technology

There is a genetic variation rs2046210 upstream of the ESR1 gene, which can significantly increase the risk of non-small cell lung cancer in people exposed to high levels of BPA

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