Gonadotropin-releasing hormone antagonist dosing regimens for the treatment of endometriosis

A technology of endometrium and antagonists, which is applied in the direction of pharmaceutical formulations, diseases, drug combinations, etc., and can solve problems such as adverse side effects, receptor insensitivity, and restrictions
CN110996956APending Publication Date: 2020-04-10KISSEI PHARMA

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KISSEI PHARMA
Publication Date
2020-04-10

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Abstract

The invention provides methods of treating endometriosis in a patient by administration of a gonadotropin-releasing hormone (GnRH) antagonist, for instance, according to dosing regimens predicated onthe patient's level of anti-Mullerian hormone (AMH) or beta 17-estradiol (E2).
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Description

technical field

[0001] The present invention relates to methods for determining the dosing regimen of a gonadotropin releasing hormone antagonist for use in the treatment of endometriosis. Background technique

[0002] Endometriosis is an estrogen-dependent gynecological condition characterized by the presence of endometrium-like tissue on the outside of the uterus and is one of the most common sex hormone-dependent diseases. The condition is mainly observed in women of reproductive age and disappears spontaneously after menopause. A chronic inflammatory response caused by ectopic endometrial cells Endometriosis can lead to infertility and a variety of painful symptoms, including dysmenorrhea, dyspareunia, chronic pelvic pain, and difficulty urinating and defecating.

[0003] The main goal of treating endometriosis is to achieve symptom relief. Treatment options for women with endometriosis-related pain are diverse and include analgesic therapy, hormone therapy, conservati...

Claims

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