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A method for enhancing the stability of allicin
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A technology of allicin and stability, which is applied in the field of enhancing the stability of allicin, which can solve problems such as instability and strict storage conditions of allicin, and achieve the effect of enhancing stability
Active Publication Date: 2021-02-05
HENAN UNIVERSITY
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Problems solved by technology
[0004] The invention proposes a method for enhancing the stability of allicin, which solves the problem of strict and unstable storage conditions of existing allicin
Method used
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Embodiment 1
[0014] A method for enhancing the stability of allicin, the steps are as follows:
[0015] (1) Weigh the same amount of allicin, 4 parts, add tocopherol, phenol, sodiumbisulfite to 3 parts, and not add to the other part, the mass ratio is 0.1:100;
[0016] (2) Add absolute ethanol to the above three solutions respectively, with a volume ratio of 1:10, and mix well;
[0017] (3) Measure 1ml of each solution in step 2, take 5 portions of each solution, put them in 1ml ampoules, seal them, and place them at room temperature.
[0018] The content of allicin in the samples placed for 12 months was determined by HPLC. The HPLC chromatographic conditions are: chromatographic column (SilGreen C 18 , 250 mm × 4.6mm, 5 µm), the mobile phase is methanol: water: formic acid (80:20:0.1), the flow rate: 1mL / min, the injection volume is 10 µl, and the detection wavelength is λ D =252nm.
[0019] Comparing the content changes of allicin in the three kinds of stabilizers and the blank all...
Embodiment 2
[0022] A method for enhancing the stability of allicin, the steps are as follows:
[0023] (1) Weigh the same amount of allicin, 4 parts, add tocopherol, phenol, sodium bisulfite to 3 parts respectively, and not add to the other part, the mass ratio is 0.5:100;
[0024] (2) Add absolute ethanol to the above three solutions respectively, with a volume ratio of 1:10, and mix well;
[0025] (3) Measure 1ml of each solution in step 2, take 5 portions of each solution, put them in 1ml ampoules, seal them, and place them at room temperature.
Embodiment 3
[0027] A method for enhancing the stability of allicin, the steps are as follows:
[0028] (1) Weigh the same amount of allicin, 4 parts, add tocopherol, phenol, sodium bisulfite to 3 parts respectively, and not add to the other part, the mass ratio is 1:100;
[0029] (2) Add absolute ethanol to the above three solutions respectively, with a volume ratio of 1:10, and mix well;
[0030] (3) Measure 1ml of each solution in step 2, take 5 portions of each solution, put them in 1ml ampoules, seal them, and place them at room temperature.
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Abstract
The invention provides a method for enhancing the stability of allicin. The steps are as follows: add a stabilizer to the allicin to obtain a stable solution, add absolute ethanol to the stable solution and mix evenly, seal the mixed solution and store it at room temperature. In the present invention, stabilizers such as tocopherol (multi-configuration mixture), phenol, and sodiumbisulfite are added to the absolute ethanol solution of allicin, and the mass ratio of the stabilizer to allicin is 0.1%-1%. After standing for one year, compared with the blank solution without adding stabilizer, the results show that the addition of tocopherol can enhance the stability by 3.4 times, the addition of phenol can enhance the stability by 6.5 times, and the addition of sodiumbisulfite can enhance the stability by 7.3 times.
Description
technical field [0001] The invention relates to the field of medicine production, in particular to a method for enhancing the stability of allicin. Background technique [0002] Allicin (Diallyl trisulfide, also known as allicin) has poor stability and is easily decomposed during high temperature sterilization, so that the terminal sterilization process cannot be used to improve the sterility level of drugs containing allicin. Reduced the shelf life of allicin drugs. In addition, the decomposition products of allicin are not easy to control. These factors have perplexed the enterprises producing allicin medicine, hindered the wide application and development prospect of allicin. [0003] Regarding the stability of allicin, Hiroyuki Fujisawa, Wu Dakang and others investigated the stability of allicin under the conditions of different concentrations of aqueous solution and ethanol solution and pH value, and compatibility with Vc. However, there is no document that enhances t...
Claims
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Application Information
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