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A pharmaceutical composition for preventing and treating pulmonary hypertension, its preparation method and application

A technology of pulmonary arterial hypertension and composition, applied in the field of medicine, can solve the problems of high cost of drug preparation and medication, insufficient treatment convenience, poor treatment effect, etc.

Active Publication Date: 2020-11-03
QINGHAI UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on this, it is necessary to provide a drug based on linalool, geraniol, myrtyl alcohol and perillyl alcohol for the problems of poor therapeutic effect of current pulmonary hypertension drugs, high cost of drug preparation and medication, and insufficient treatment convenience. Active ingredients in therapeutic drugs

Method used

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  • A pharmaceutical composition for preventing and treating pulmonary hypertension, its preparation method and application

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Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] A preparation method of a pharmaceutical composition for preventing and treating pulmonary hypertension, comprising the following steps: making the above-mentioned active components and pharmaceutically acceptable auxiliary materials into powders, pills, granules, capsules, Tablets or liquid preparations, etc.

[0022] Application of the above pharmaceutical composition for preventing and treating pulmonary hypertension in the preparation of medicines for treating pulmonary hypertension.

[0023] Compared with the prior art, the present invention has the following advantages:

[0024] The active components of the pharmaceutical composition of the present invention are linalool, geraniol, myrtyl alcohol and perillyl alcohol, which can significantly reduce the pulmonary hypertension caused by hypoxia, and the preparation method of the pharmaceutical preparation of the present invention is simple, the cost of medication is low, and the Improve the convenience of treatment...

Embodiment

[0026] (1) Preparation of active components:

[0027] Weigh linalool, geraniol, myrtyl alcohol and perillyl alcohol according to the mass ratio of 3:3.5:2:1, and mix them for later use.

[0028] (2) Pharmacological activity experiment:

[0029] lowering pulmonary arterial pressure

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Abstract

The invention relates to a pharmaceutical composition for preventing and treating pulmonary hypertension as well as a preparation method and application thereof. The pharmaceutical composition is prepared from an active component and pharmaceutically acceptable auxiliary materials, wherein the active component is prepared by mixing linalool, geraniol, myrtanol and perillyl alcohol. The preparationmethod of the pharmaceutical composition comprises a step of preparing powder, a pill, a granule, a capsule, a tablet, a liquid preparation or the like from the active component and the pharmaceutically acceptable auxiliary materials according to a pharmaceutically conventional method. The pharmaceutical composition disclosed by the invention can be used for preparing medicines and health-care products for treating pulmonary hypertension. The active component composed of linalool, geraniol, myrtanol and perillyl alcohol of the pharmaceutical composition can significantly reduce pulmonary hypertension caused by hypoxia; the preparation method of the pharmaceutical preparation is simple and convenient; the medication cost is low; and the treatment convenience of pulmonary hypertension is improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for preventing and treating pulmonary hypertension, a preparation method and application thereof. Background technique [0002] Pulmonary arterial hypertension (PAH) is a group of diseases or clinical syndromes characterized by elevated pulmonary artery pressure and pulmonary vascular resistance caused by different etiologies. Its pathogenesis includes vasoconstriction, vascular remodeling and thrombosis. The classification system proposed by the International Symposium on Primary Pulmonary Hypertension divides pulmonary hypertension into 5 types: 1) pulmonary hypertension associated with respiratory disease and / or hypoxemia; 2) pulmonary venous hypertension; 3) chronic thrombosis and / or or embolism disease; 4) pulmonary arteriolar hypertension; 5) pulmonary hypertension caused by diseases directly affecting pulmonary vascular tissue. If PAH is not ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/045A61P11/00A61P9/12
CPCA61K31/045A61P9/12A61P11/00A61K2300/00
Inventor 李占强芦殿香苏姗姗南星梅马可杨占婷李珂华玉美多靳国恩杨全余嘎琴贾豆豆
Owner QINGHAI UNIVERSITY