Antibacterial agent composition and application

A technology of composition and antibacterial agent, which is applied in the field of antibacterial agent preparation, achieves the effects of environmental protection biocompatibility, improvement of mechanical properties and antibacterial properties, and simple preparation process

Inactive Publication Date: 2020-04-28
云南伦扬科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of carbon dots as nanozymes is currently mainly used in the detection field, such as glucose, hydrogen peroxide, uric acid, cholesterol, etc., and there are few reports on microbial antibacterial applications.

Method used

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  • Antibacterial agent composition and application
  • Antibacterial agent composition and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: antibacterial agent is to escherichia coli bacteriostatic bactericidal effect

[0019] 1, the chitosan preparation method of loaded nitrogen, iodine-doped carbon dot comprises the following steps:

[0020] Preparation of chitosan nanoparticles: Dissolve 1 part of chitosan in 100 parts of 1% acetic acid solution, add (v / v) 0.4% Tween-20 aqueous solution, and mix (w / v) 0.04 % sodium tripolyphosphate aqueous solution was added dropwise in the above solution, the pH was adjusted to 5.0, stirred for 10min, which was chitosan nanoparticles;

[0021] Preparation of iodine nitrogen doped carbon dots: Weigh 1 part of iodixanol, add 100 parts of ultrapure water, mix and dissolve, add 0.3 parts of ethylenediamine, ultrasonicate for 10 minutes, and transfer to a polytetrafluoroethylene reactor, at 180 ° C Heating for 8 hours, after natural cooling, filter with a pore size of 0.22 μm filter membrane, and then use a dialysis bag with a molecular weight cut-off of 3...

Embodiment 2

[0031] Embodiment 2: antibacterial agent is to staphylococcus aureus bacteriostatic bactericidal effect

[0032] 1, the chitosan preparation method of loaded nitrogen, iodine-doped carbon dot comprises the following steps:

[0033] Preparation of chitosan nanoparticles: Weigh 3 parts of chitosan and dissolve in 300 parts of 1% acetic acid solution, add (v / v) 0.6% Tween-20 aqueous solution, and mix (w / v) 0.06 % sodium tripolyphosphate aqueous solution was added dropwise to the above solution, the pH was adjusted to 5.0, and stirred for 15 min to form chitosan nanoparticles;

[0034] Preparation of iodine nitrogen doped carbon dots: Weigh 2 parts of iodixanol, add 120 parts of ultrapure water, mix and dissolve, add 0.5 parts of ethylenediamine, sonicate for 15 min, and transfer to a polytetrafluoroethylene reactor, at 180 Heating at ℃ for 10 h, after natural cooling, first filter with a filter membrane with a pore size of 0.22 μm, and then use a dialysis bag with a molecula...

Embodiment 3

[0045] Embodiment 3: antibacterial agent is used in tipping paper for cigarette

[0046] 1, the chitosan preparation method of loaded nitrogen, iodine-doped carbon dot comprises the following steps:

[0047] Preparation of chitosan nanoparticles: Weigh 5 parts of chitosan and dissolve in 500 parts of 1% acetic acid solution, add (v / v) 0.8% Tween-20 aqueous solution, and mix (w / v) 0.08 % sodium tripolyphosphate aqueous solution is added dropwise in the above-mentioned solution, pH is adjusted to 5.0, stirs 20min, namely chitosan nano-particle;

[0048] Preparation of carbon dots doped with iodine nitrogen: Weigh 3 parts of iodixanol, add 150 parts of ultrapure water, mix and dissolve, add 1 part of ethylenediamine, sonicate for 20 minutes, and transfer to a polytetrafluoroethylene reactor, at 180 ° C Heating for 12 hours, after natural cooling, filter with a filter membrane with a pore size of 0.22 μm, and then perform dialysis treatment with a dialysis bag with a molecula...

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PUM

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Abstract

Iodo-cosanol and ethylenediamine are used as raw materials to synthesize nitrogen-doped and iodine-doped carbon dots by a one-step hydrothermal method, the enzyme characteristics are simulated based on the synthesizedcarbon dots, nitrogen and iodine doped carbon dots are fixed on the surfaces of chitosan molecules with high biological matching performance, and the formed compound is mixed with hydrogen peroxide to be used as a novel antibacterial agent; the carbon dot nano-enzyme and hydrogen peroxide coexist, and the oxidation activity of the nano-enzyme promotes the oxidation process of bacterial cells and the consumption of antioxidant biomolecules so that the oxygen products including H2O2 and other accumulated antibacterial activities from reactive oxygen species (ROS) are reduced; meanwhile, the chitosan also has better antibacterial property and generates a synergistic antibacterial effect. The antibacterial agent is mixed with printing ink to be used for resisting bacteria of tipping paper for cigarettes, the antibacterial performance of the antibacterial agent meets the requirements of the tobacco industry, and the antibacterial agent is a safe, environment-friendly and effective novel antibacterial agent.

Description

technical field [0001] The invention belongs to the technical field of antibacterial agent preparation, and in particular relates to an antibacterial agent composition and its application. Background technique [0002] Cigarette tipping paper is one of the important materials for the production of cigarettes. It is based on the base paper of cigarette tipping, and through pre-press design, printing processing and post-press processing, the filter tip is connected with the cigarette. A special paper. Since the tipping paper for cigarettes is in direct contact with the smoker's lips, the antibacterial properties are also valued by cigarette factories and consumers. The use of antibacterial agents on paper has a long history, and is mainly divided into three categories: natural antibacterial agents, organic antibacterial agents, and inorganic antibacterial agents. The antibacterial mechanisms of different antibacterial agents are also different. At present, the antibacterial ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/16A01N59/12A01N59/00A01P1/00
CPCA01N43/16A01N59/00A01N59/12
Inventor 陈子昭高哲杨亚玲
Owner 云南伦扬科技有限公司
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