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A kind of acid-soluble rapid gelling self-healing hydrogel and its preparation method and application

A gelation and self-healing technology, which is applied in the field of biomedical polymer materials, can solve the problems of unevaluated degradation performance and self-healing performance, the inability to confirm whether the gel is suitable, and the inability to use first aid in wartime, etc., to achieve Conducive to industrialization, mild preparation conditions and good performance

Active Publication Date: 2021-06-08
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are still some deficiencies in many hydrogels, such as: patent application CN109749137A has announced a chitosan hydrogel dressing, although the dressing gel time is fast, has good antibacterial properties, and can promote wound healing, but it has not been evaluated. Degradability and self-healing properties, it is impossible to confirm whether the gel is suitable for war wounds, because dressings used in war wounds need to have good degradation properties so that they will not cause secondary trauma when replaced, and should also It has good self-healing properties, and can heal itself in time to protect the skin and isolate harmful substances after being damaged by external force; the patent application CN108841013A discloses a chitosan hydrogel, which has good biocompatibility and biological Degradability, but its preparation process is relatively complicated, so it cannot be used for outdoor first aid in wartime

Method used

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  • A kind of acid-soluble rapid gelling self-healing hydrogel and its preparation method and application
  • A kind of acid-soluble rapid gelling self-healing hydrogel and its preparation method and application
  • A kind of acid-soluble rapid gelling self-healing hydrogel and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (1) Preparation of O-carboxymethyl chitosan. Weigh 1.00 g of chitosan (with a degree of polymerization of 427-854) in a 50 mL reaction flask, add 4 mL of 50 wt % sodium hydroxide solution, and alkalize it at -20° C. for 10 hours. Weigh 3.30g of monochloroacetic acid, dissolve it in 20mL of isopropanol, add it into the reaction bottle at a rate of 5 seconds per drop, and carry out the reaction at a constant temperature of 45°C with stirring for 2h. Then, 6 mL of 50 wt % sodium hydroxide solution was added in one go, and the stirring was stopped after 4 hours of reaction, and the obtained product was a mixture of oily liquid and white solid. The obtained mixture was filtered, and the filter residue was washed twice with absolute ethanol and acetone successively. Fully dissolve the filter residue in 80 mL deionized water at room temperature, and use 0.5 mol·L -1 The pH of the solution was adjusted to neutral with hydrochloric acid, and a large amount of white flocculent ...

Embodiment 2

[0071] (1) Preparation of O-carboxymethyl chitosan. Weigh 2.50g chitosan (polymerization degree: 427-854) into a 150mL reaction bottle, add 10mL 50wt% sodium hydroxide solution, and alkalize it at -20°C for 10 hours. Weigh 8.25g of monochloroacetic acid, dissolve it in 50mL of isopropanol, add it into the reaction flask at a rate of 7 seconds per drop, and carry out the reaction at a constant temperature of 70°C with stirring for 2 hours. Then, 15 mL of 50 wt % sodium hydroxide solution was added at one time, and the stirring was stopped after 2 h of reaction, and the obtained product was a mixture of oily liquid and white solid. The obtained mixture was filtered, and the filter residue was washed twice with absolute ethanol and acetone successively. Fully dissolve the filter residue in 200 mL deionized water at room temperature, and use 0.5 mol·L -1 The pH of the solution was adjusted to neutral with hydrochloric acid, and a large amount of white flocculent precipitate was ...

Embodiment 3

[0083] (1) Preparation of O-carboxymethyl chitosan. Weigh 5.00 g of chitosan (polymerization degree 427-854) into a 150 mL reaction flask, add 20 mL of 50 wt % sodium hydroxide solution, and alkalize it at -20° C. for 10 hours. Weigh 16.50g of monochloroacetic acid, dissolve it in 100mL of isopropanol, add it into the reaction flask at a rate of 3 seconds per drop, and carry out the reaction at a constant temperature of 30°C with stirring for 2h. Then, 30 mL of 50 wt % sodium hydroxide solution was added at one time, and the stirring was stopped after 4 hours of reaction, and the obtained product was a mixture of oily liquid and white solid. The obtained mixture was filtered, and the filter residue was washed twice with absolute ethanol and acetone successively. Fully dissolve the filter residue in 300 mL deionized water at room temperature, and use 0.5 mol·L -1 The pH of the solution was adjusted to neutral with hydrochloric acid, and a large amount of white flocculent prec...

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Abstract

The invention belongs to the technical field of high-molecular polymer materials for biomedicine, and discloses a high-strength hydrogel capable of self-healing and rapid gelation and a preparation method thereof. Specifically, it is composed of water-soluble chitosan polymers with amino groups and 4,4'-dimethyloxy-two-[(2-ethoxy-(2-methoxy-1,3-dioxolane Alkane-4-ethylene) acetaldehyde] cross-linked. After cross-linking the water-soluble polymers with amino groups and small molecules with aldehyde groups, a three-dimensional network structure is formed, which can carry water-soluble drugs, bioactive factors, slow-release Carrier etc. endow the hydrogel wound dressing with functions such as antibacterial, anti-inflammation, and promoting healing.In addition, the hydrogel of the present invention has rapid gelation, self-healing performance, excellent biocompatibility, appropriate mechanical strength, operation With the advantages of simplicity and low cost, it can be used as a polymer hydrogel wound dressing and has certain application prospects in the fields of drug release and skin wound repair.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, in particular to an acid-dissolvable rapid-gelling self-healing hydrogel and its preparation method and application. Background technique [0002] Hemorrhage and infection are considered to be the two major "killers" of war trauma. Due to the urgency of the battlefield environment, temporarily covering the wound with dressings is a common method for early treatment of war wounds. Traditional dressings such as cotton dressings and foam plastic bandages are easy to make, cheap and reusable. But this kind of dressing is easy to breed bacteria, the wound surface dries quickly, and it is easy to adhere to the wound surface, and it is easy to cause secondary trauma when changing the dressing. Therefore, the research and development of new dressings with good performance to protect wounds, control bleeding, prevent infection and be easy to remove for follow-up treatment is of great signific...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/24C08J3/075C08L5/08A61L26/00
CPCA61L26/0023A61L26/0061A61L26/0066A61L26/008A61L2300/232A61L2300/404A61L2300/412A61L2400/04C08J3/075C08J3/24C08J2305/08C08L5/08
Inventor 章莉娟黄诗雅温李阳杨谦张静
Owner SOUTH CHINA UNIV OF TECH
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