Surface acoustic wave regulated high-flux micro-droplet generation device and surface acoustic wave regulated high-flux micro-droplet generation method

Abstract

The invention discloses a surface acoustic wave regulated high-flux micro-droplet generation device and a surface acoustic wave regulated high-flux micro-droplet generation method. The device comprises an interdigital transducer, wherein an arc-shaped interdigital electrode is manufactured on the interdigital transducer, and a PDMS micro-flow channel system is bonded to the upper portion of the interdigital transducer, and is formed by bonding a top-layer PDMS flow channel, a middle-layer PDMS flow channel and a bottom-layer PDMS flow channel. The method comprises the following steps: fixing the device on an objective table of a microscope; adjusting a dispersion phase and a continuous phase to corresponding flow rates through an injection pump; at each T-shaped micro-flow channel in the device, shearing the dispersion phase into micro-droplets by the dispersion phase, pressing down the output button of a signal generator, and generating converged acoustic surface waves on the interdigital transducer, wherein an acoustic pressure field acts on the continuous phase to increase corresponding flow resistance, and is used as an acoustic valve to regulate and control the flow velocity of the continuous phase, so that the regulation and control of the droplet size are realized. According to the invention, the amplitude and the frequency of the input sine voltage are adjusted while the high-flux generation of the liquid drops is ensured, and the generation size of the micro-liquid drops can be flexibly regulated and controlled in real time.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to a device and method for generating high-flux microdroplets regulated by surface acoustic waves. Background technique [0002] Microdroplets are widely used in biomedical research and chemical material manufacturing, among which the method of microdroplet generation is very important, and different methods vary greatly in droplet generation rate and uniformity. With the development of microfluidic technology, passive micro-droplet generation methods and active micro-droplet generation methods have emerged. At present, the passive generation methods of micro-droplets mainly include co-flow method, flow convergence method, T-shaped micro-channel method and derivative methods based on the above methods. By adjusting the input pressure of the dispersed phase and the continuous phase, the dispersed phase can be continuously The phase is rapidly sheared into micro-droplets, and t...

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Problems solved by technology

[0004] However, in the above methods of acoustically controlled droplet generation, most of the microfluidic devices used are two-dimensional flow channels, and their generation rate is limited to a certain extent, which is not suitable for the generation of large-flux microdroplets, especially when large-scale liquid flow is required. When droplets are generated rapidly, the generation rate is difficult to meet the needs, and a high-throughput microfluidic generation device with active droplet real-time regulation is urgently needed

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