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Method for identifying liver cirrhosis based on serum N-carbohydrate fingerprint spectrum

A fingerprint and serum technology, applied in the field of clinical medical diagnostics, can solve the problems of high risk and trauma, application limitations, etc., and achieve the effect of improving sensitivity and specificity

Inactive Publication Date: 2020-05-12
高春芳
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] At present, the gold standard for the diagnosis of liver cirrhosis is liver biopsy, but its risk and trauma are relatively high, which limits its clinical application

Method used

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  • Method for identifying liver cirrhosis based on serum N-carbohydrate fingerprint spectrum
  • Method for identifying liver cirrhosis based on serum N-carbohydrate fingerprint spectrum
  • Method for identifying liver cirrhosis based on serum N-carbohydrate fingerprint spectrum

Examples

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Effect test

Embodiment

[0025] Example: Detection and Analysis of Serum N-Glycan NGFP Levels in Liver Cirrhosis (LC) and CHB and Healthy Physical Examination Crowds

[0026] From 2007 to 2018, 374 patients diagnosed with LC, 182 patients diagnosed with CHB, and 182 healthy individuals were collected. All the above-mentioned personnel drew blood on an empty stomach. After standing at room temperature for 30 minutes, centrifuge at 3000rpm for 10 minutes, absorb the upper serum, and store it in a -80°C refrigerator for later use. The basic information of the selected patients is shown in Table 1:

[0027] Table 1 Basic information of the selected patients

[0028]

[0029]

[0030] Note: Continuous variables with normal distribution are expressed as mean ± standard deviation, and t-test is used for comparison between groups; continuous variables with non-normal distribution are expressed as median (interquartile range), and comparison between groups is performed with Non-parametric test; classifi...

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Abstract

The invention belongs to the field of clinical medical diagnostics, relates to seroglycoid N-carbohydrate glycome detection, and particularly relates to a method for identifying liver cirrhosis basedon a serum N-carbohydrate fingerprint spectrum. A log (P2 / P8) value is calculated. Liver cirrhosis is the final stage of various liver diseases and is the fourteenth major lethal cause of the world. At present, the gold standard of liver cirrhosis diagnosis is liver tissue biopsy, and the risk and trauma of the liver tissue biopsy are large, so that the clinical application of the liver tissue biopsy is limited. The serological marker, as a non-invasive detection means for liver cirrhosis patients, is clinically paid attention to. On the basis, the invention provides a method for identifying liver cirrhosis by N-carbohydrate spectra and a corresponding detection system. The detection method and the detection system are used for early screening and diagnosis of LC; the sensitivity and specificity of the detection method and the detection system are improved compared with those of liver fiber indexes, namely, hyaluronic acid and IV type collagen; and it can be considered that the log (P2 / P8) is a characteristic serological marker for LC diagnosis.

Description

technical field [0001] The invention belongs to the field of clinical medical diagnosis, and in particular relates to a method for detecting serum N-glycolog (P2 / P8), a detection system and an application thereof. Background technique [0002] Liver fibrosis is an abnormal repair caused by one or more causes of long-term repeated effects, leading to diffuse liver damage in the liver, among which liver cirrhosis (liver cirrhosis, LC) is the terminal stage of various liver diseases as advanced liver fibrosis. Currently, cirrhosis has become the 14th leading cause of death in the world. In most developed countries, the main causes of cirrhosis are hepatitis C virus (HCV), alcoholism and more and more non-alcoholic liver diseases. In my country, hepatitis B virus (HBV) infection is the main cause of hepatitis, liver cirrhosis, and liver cancer. Every year, 2.5%-3% of chronic hepatitis B develops into liver cirrhosis. Due to the atypical clinical manifestations of liver cirrhosi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/447
CPCG01N27/44726
Inventor 高春芳黄晨军房萌
Owner 高春芳
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