Method for preparing hydroxyapatite/L-polylactide composite bone scaffold

A technology of L-polylactic acid and hydroxyapatite, which is used in medical science, tissue regeneration, prosthesis, etc., can solve problems such as unsatisfactory strength, incompatibility between inorganic particles and polymer interfaces, and achieve excellent interface bonding ability, improve Mechanical properties, the effect of improving strength

Active Publication Date: 2020-05-22
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of incompatibility between inorganic particles and polymer interfaces and unsatisfactory strength in existing bone scaffold materials, the present invention provides a method for preparing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Weigh 400 mg of dopamine and dissolve it in 200 mL of Tris-HCl buffer solution (pH=8.5) to prepare a polydopamine solution, then weigh 0.2 mg of PLLA powder with a particle size of 50 μm and a melting point of 180° C. into the polydopamine solution , the polydopamine-modified PLLA suspension was uniformly prepared by magnetic stirring and ultrasonic dispersion mixing, wherein the magnetic stirring time was 30 min, the magnetic stirring speed was 500 r / min, the stirring temperature was 50 ° C, the ultrasonic dispersion time was 40 min, and the ultrasonic dispersion temperature was 50°C;

[0048] (2) The polydopamine-modified PLLA suspension is centrifuged, washed with distilled water, dried, and ground to prepare polydopamine-modified PLLA powder; wherein the centrifugal separation speed is 2000r / min, the time is 25min, the drying temperature is 50°C, and the holding time 18h;

[0049] (3) Put the polydopamine-modified PLLA powder into 1.5 times the simulated body f...

Embodiment 2

[0065] Compared with Example 1, the main difference is that the in situ generation time of HAP is 1 day, and the specific operation is as follows:

[0066] (1) Weigh 400 mg of dopamine and dissolve it in 200 mL of Tris-HCl buffer solution (pH=8.5) to prepare a polydopamine solution, then weigh 0.2 mg of PLLA powder with a particle size of 50 μm and a melting point of 180° C. into the polydopamine solution , the polydopamine-modified PLLA suspension was uniformly prepared by magnetic stirring and ultrasonic dispersion mixing, wherein the magnetic stirring time was 30 min, the magnetic stirring speed was 500 r / min, the stirring temperature was 50 ° C, the ultrasonic dispersion time was 40 min, and the ultrasonic dispersion temperature was 50°C;

[0067] (2) The polydopamine-modified PLLA suspension is centrifuged, washed with distilled water, dried, and ground to prepare polydopamine-modified PLLA powder; wherein the centrifugal separation speed is 2000r / min, the time is 25min, ...

Embodiment 3

[0072] Compared with Example 1, the main difference is that the in-situ generation time of HAP is 5 days, and the specific operation is as follows:

[0073] (1) Weigh 400 mg of dopamine and dissolve it in 200 mL of Tris-HCl buffer solution (pH=8.5) to prepare a polydopamine solution, then weigh 0.2 mg of PLLA powder with a particle size of 50 μm and a melting point of 180° C. into the polydopamine solution , the polydopamine-modified PLLA suspension was uniformly prepared by magnetic stirring and ultrasonic dispersion mixing, wherein the magnetic stirring time was 30 min, the magnetic stirring speed was 500 r / min, the stirring temperature was 50 ° C, the ultrasonic dispersion time was 40 min, and the ultrasonic dispersion temperature was 50°C;

[0074] (2) The polydopamine-modified PLLA suspension is centrifuged, washed with distilled water, dried, and ground to prepare polydopamine-modified PLLA powder; wherein the centrifugal separation speed is 2000r / min, the time is 25min,...

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Abstract

The invention belongs to the field of bone scaffold preparation, and particularly discloses a method for preparing a hydroxyapatite/L-polylactide composite bone scaffold. The method comprises the following steps: carrying out surface modification on L-polylactide powder by utilizing polydopamine; soaking the modified powder in a simulated body fluid to generate hydroxyapatite on the surface of theL-polylactide powder in situ, filtering, cleaning, drying and grinding the obtained powder to obtain a composite powder, and performing selective laser sintering on the obtained composite powder to prepare the hydroxyapatite/L-polylactide composite bone scaffold. In the composite bone scaffold prepared by the method, the hydroxyapatite is uniformly distributed in a L-polylactide matrix, and strong interface bonding exists between the hydroxyapatite and the L-polylactide.

Description

technical field [0001] The invention belongs to the technical field of medical implant preparation, and in particular relates to a preparation method of a hydroxyapatite / L-polylactic acid composite bone scaffold. Background technique [0002] Poly-L-lactic acid (PLLA) is a degradable material with good biocompatibility. It can be hydrolyzed into lactic acid in the body and participate in the metabolism of the human body. The final degradation products are carbon dioxide and water. It is non-toxic and harmless to the human body. One of the most widely used synthetic polymers. However, PLLA has no biological activity, and it is difficult to form a strong osseointegration with bone tissue. In addition, its degradation intermediate product is acidic, which can easily cause aseptic inflammation. The chemical composition and structure of hydroxyapatite (HAP) are very similar to those of human bone tissue. It has excellent bone bonding ability and can induce and promote bone growt...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/18A61L27/12A61L27/56
CPCA61L27/12A61L27/18A61L27/50A61L27/56A61L2430/02C08L67/04
Inventor 冯佩帅词俊
Owner CENT SOUTH UNIV
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