Methods and compositions for treatment of pain using capsaicin

A kind of capsaicin, the technology of composition, is applied in the field of using capsaicin to treat pain and composition

Pending Publication Date: 2020-05-26
中枢疗法公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Due to the unmet need for access to additional treatment options for pain relief, particularly ones that do not tolerate the addiction issues associated with many opioid-based pain treatments, there is a need for new approaches to pain management

Method used

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  • Methods and compositions for treatment of pain using capsaicin
  • Methods and compositions for treatment of pain using capsaicin
  • Methods and compositions for treatment of pain using capsaicin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach No

[0348] Embodiment No. 1. A method of improving osteoarthritic knee joint pain in a human patient, comprising:

[0349] a. applying the cooling article to the outer surface of the knee of a human patient presenting with osteoarthritic knee pain for a duration of about 15 minutes; then

[0350] b. administering by injection a pharmaceutical composition comprising a single pain relieving agent selected from lidocaine and its pharmaceutically acceptable salts into the intra-articular space of the knee joint so as to deliver a dose ranging from about 0.1 g to about 0.5 g of lidocaine; then

[0351] c. applying a cooling article to the outer surface of the knee for a duration of about 30 minutes to obtain a temperature of the skin in contact with the cooling article in the range of about 7°C to about 30°C; then

[0352] d. administering a pharmaceutical composition comprising capsaicin by injection into the intra-articular space of said knee joint so as to deliver a dose of capsaicin...

Embodiment approach No1

[0721] Embodiment No. 1: A method of alleviating a transient burning sensation caused by injection of capsaicin into tissue adjacent to an intermetatarsal neuroma comprising:

[0722] a. A cooling article is applied to the skin of a human patient in need of pain relief therapy near an intermetatarsal neuroma for a duration of about 15 minutes, wherein for application to the patient's foot, the cooling article has an outer surface temperature in the range of from about 5°C to about 15°C; then

[0723] b. administering by injection a pharmaceutical composition comprising a single pain relieving agent selected from lidocaine and pharmaceutically acceptable salts thereof into tissue adjacent to said intermetatarsal neuroma so as to deliver a dose ranging from about 30 mg to about 50 mg amount of lidocaine;

[0724] c. applying the cooling article to the skin of a human patient in need of pain relief therapy near an intermetatarsal neuroma for a duration of about 30 minutes, where...

Embodiment approach No22

[0748] Embodiment No. 22: The method of any one of Embodiments no. 1-11, wherein for application to the patient's foot, the cooling article has an outer surface temperature of about 10°C.

[0749] Embodiment No. 23: The method of any one of Embodiments no. 1-11, wherein for application to the patient's foot, the cooling article has an outer surface temperature of about 9°C.

[0750] Embodiment No. 24: The method of any one of Embodiments no. 1-11, wherein for application to the patient's foot, the cooling article has an outer surface temperature of about 8°C.

[0751] Embodiment No. 25: The method of any one of Embodiments no. 1-11, wherein for application to the patient's foot, the cooling article has an outer surface temperature of about 7°C.

[0752] Embodiment No. 26 The method of any one of Embodiment nos. 1-11, wherein for application to the patient's foot, the cooling article has an outer surface temperature of about 6°C.

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Abstract

The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled viaa circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit and priority of U.S. Provisional Patent Application Serial No. 62 / 535,003, filed July 20, 2017, the contents of which are incorporated herein by reference. [0003] field of invention [0004] The present invention provides methods and compositions for the treatment of pain, such as arthralgia, using capsaicin in a procedure that reduces the temperature of tissue exposed to capsaicin through the use of controlled cooling, optionally in combination with the use of local anesthetics, to relieve pain caused by capsaicin administration. Causes a momentary burning sensation felt by the patient. Background technique [0005] Pain can function as a protective mechanism that enables healthy humans and animals to avoid tissue damage and / or prevent further damage to damaged tissue. However, there are many examples where the pain persists beyond its use. This needless toleration of pain can im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/167A61K31/165A61P19/02A61P29/02
CPCA61K31/165A61K31/167A61P29/02A61P19/02A61K2300/00A61F7/10A61F2007/0042A61K9/0014A61K9/0019
Inventor J·N·卡姆普贝尔P·D·汉森G·F·穆索D·奥斯托维奇R·史蒂文
Owner 中枢疗法公司
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