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A kind of boscalid emulsion and preparation method thereof

A technology of boscalid and emulsion, which is applied in the field of boscalid emulsion and its preparation, can solve the problems of poor physical dispersion and stability, affecting the efficacy of boscalid, etc., so as to improve the effective utilization rate and improve the drug efficacy. Effect, the effect of prolonging the duration of effect

Active Publication Date: 2022-04-19
GUIZHOU TOBACCO SCI RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing boscalid suspensions and suspoemulsions have poor physical dispersibility and stability, especially in storage, they are prone to stratification and precipitation, which affects the normal performance of boscalid.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The first step, preparation of boscalid oil phase solution: after heating 10g of boscalid to 143°C for melting, dissolve in 10ml of mixed solvent (ethyl acetate: dimethyl carbonate: ethyl lactate) at a temperature of 10°C The volume ratio is 6:5:5), and the boscalid stock solution of 1 g / ml is prepared;

[0028] The second step, preparation of gluten hydrolyzed suspension: 5g of gluten was added to 10mL of 2% lactic acid aqueous solution (pH = 3), hydrolyzed in a water bath at 50°C for 1 hour, and a gluten hydrolyzed suspension with a concentration of 500mg / ml was obtained. liquid;

[0029] The third step, preparation of boscalid emulsion: under 1000r / min mechanical stirring, slowly add 10ml gluten hydrolyzed suspension, 20ml glycerin, 2.5ml sophorolipid, diatomaceous earth to 10ml boscalid stock solution 0.4g, boscalid emulsion;

[0030] The fourth step, preparation of boscalid emulsion: after stirring for 10 minutes, add 7.5ml xanthan gum solution (concentration 10m...

Embodiment 2

[0032] The first step, preparation of boscalid oil phase solution: after heating 15g of boscalid to 147°C for melting, dissolve in 10ml of mixed solvent (ethyl acetate: dimethyl carbonate: ethyl lactate) at a temperature of 20°C The volume ratio is 6:5:5), and the boscalid stock solution of 1.5g / ml is prepared;

[0033] The second step, preparation of gluten hydrolyzed suspension: 15g of gluten was added to 10mL of 2% lactic acid aqueous solution (pH=3), hydrolyzed in a water bath at 64°C for 2h, and the gluten hydrolyzed suspension with a concentration of 150mg / ml was obtained. liquid;

[0034] The third step, preparation of boscalid emulsion: under 1500r / min mechanical stirring, slowly add 10ml gluten hydrolyzed suspension, 20ml glycerin, 2.5ml sophorolipid, diatomaceous earth to 10ml boscalid stock solution 0.4g, boscalid emulsion;

[0035] The fourth step, preparation of boscalid emulsion: after stirring for 30 minutes, add 7.5ml xanthan gum solution (concentration 10mg / ...

Embodiment 3

[0037] The first step, preparation of boscalid oil phase solution: after heating 25g of boscalid to 150°C for melting, dissolve in 10ml of mixed solvent (ethyl acetate: dimethyl carbonate: ethyl lactate) at a temperature of 25°C Volume ratio is 7:5::5), is prepared into 2.5g / ml boscalid stock solution;

[0038] The second step, preparation of gluten hydrolyzed suspension: 20g of gluten was added to 10mL of 2% lactic acid aqueous solution (pH=2.5), and hydrolyzed in a water bath at 58°C for 2h to obtain a gluten hydrolyzed suspension with a concentration of 2g / ml. liquid;

[0039] The third step, preparation of boscalid emulsion: under 1500r / min mechanical stirring, slowly add 10ml gluten hydrolyzed suspension, 20ml glycerin, 2.5ml sophorolipid, diatomaceous earth to 10ml boscalid stock solution 0.4g, boscalid emulsion;

[0040] The fourth step, preparation of boscalid emulsion: after stirring for 25 minutes, add 7.5ml xanthan gum solution (concentration 10mg / ml) to the bosca...

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Abstract

The present invention discloses a boscalid emulsion, comprising: boscalid oil phase solution and gluten hydrolyzed suspension, wherein, boscalid molecules are adsorbed around the gluten oligopeptide chain, and boscalid Bacteramine molecules and gluten oligopeptide chains are cross-linked to form a network chain structure. The invention also discloses a method for preparing the boscalid emulsion. Wheat gluten will produce amino acids and polypeptides after hydrolysis. Due to the electrostatic adsorption between the amino groups in amino acids and polypeptides and the ring structure in boscalid, boscalid molecules will be adsorbed around the gluten oligopeptide chain , and boscalid molecules and gluten oligopeptide chains are cross-linked to form a network chain structure, which makes the drug evenly dispersed and combined more closely, which can prolong the duration of action and improve the effective utilization rate of boscalid.

Description

technical field [0001] The invention relates to a boscalid emulsion and a preparation method thereof, belonging to the field of boscalid fungicides. Background technique [0002] Boscalid (common name: Boscalid) is a new type of nicotinamide systemic fungicide developed by BASF, Germany. It is an inhibitor of succinate coenzyme Q reductase in the mitochondrial respiratory chain. It mainly controls many diseases such as powdery mildew, gray mold, sclerotinia, brown rot and root rot, and also has a good control effect on tobacco red spot disease, but the cost of imported boscalid formulations is relatively high. Difficult to popularize and apply. [0003] Wheat gluten is a natural protein extracted from wheat (flour). It has viscosity, elasticity, extensibility, film-forming properties and liposuction properties. It can be hydrolyzed by acid, alkali and protease to form a variety of amino acids. peptide chain. At the same time, due to its good biocompatibility, non-toxic an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/40A01N25/04A01N25/08A01P3/00
CPCA01N43/40A01N25/04A01N25/08
Inventor 陈兴江汪汉成杨磊孟建玉朱经纬刘杰代园凤宋光龙李磊磊
Owner GUIZHOU TOBACCO SCI RES INST
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